Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.12.7.2: ferredoxin hydrogenase

This is an abbreviated version!
For detailed information about ferredoxin hydrogenase, go to the full flat file.

Word Map on EC 1.12.7.2

Reaction

H2
+
oxidized ferredoxin
=
reduced ferredoxin
+ 2 H+

Synonyms

bidirectional hydrogenase, C-MBH, CooH, CpI, DDH, DdHydAB, EC 1.12.1.1, EC 1.12.7.1, EC 1.18.3.1, EC 1.18.99.1, EC 1.98.1.1, Ech hydrogenase, EHb, EhbM, EhbN, energy-conserving hydrogenase B, energy-converting hydrogenase, Fe hydrogenlyase, Fe-Fe hydrogenase, Fe-H2ase, Fe-hydrogenase, ferredoxin-dependent [FeFe] hydrogenase, ferredoxin-dependent [FeFe]-hydrogenase, H2 oxidizing hydrogenase, H2 producing hydrogenase [ambiguous], HYD1, HYD2, hydA, HydA1, HydA2, hydrogen-lyase [ambiguous], hydrogenase (ferredoxin), hydrogenase I, hydrogenase II, hydrogenase of the Fe-only type, hydrogenlyase, hydrogenlyase [ambiguous], Mbh, MBH hydrogenase, MbhJ, MbhJKLN, MbhK, MbhL, MDH, membrane bound NiFe hydrogenase, membrane-bound hydrogenase, NiFe hydrogenase, reversible Fe-hydrogenase, uptake hydrogenase [ambiguous], [FeFe] hydrogenase, [FeFe] hydrogenase HydA1, [FeFe]-hydrogenase, [Fe]-hydrogenase, [Ni-Fe] hydrogenase, [NiFeSe] Hase, [NiFeSe] hydrogenase

ECTree

     1 Oxidoreductases
         1.12 Acting on hydrogen as donor
             1.12.7 With an iron-sulfur protein as acceptor
                1.12.7.2 ferredoxin hydrogenase

Engineering

Engineering on EC 1.12.7.2 - ferredoxin hydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D102K
-
leads to lower binding free energies and higher association rate with [2Fe2S]-ferredoxin FDX1 and is thus a promising target for improving hydrogen production rates in engineered organisms
D102K/E221K
-
double mutant enhances association rate constant
D102K/T99K
-
double mutant enhances association rate constant
E221K
-
higher association rate with [2Fe2S]-ferredoxin FDX1
M214K
-
least enhancement of association rate with [2Fe2S]-ferredoxin FDX1, destabilizes binding complexes
T99K
-
leads to lower binding free energies and higher association rate with [2Fe2S]-ferredoxin FDX1 and is thus a promising target for improving hydrogen production rates in engineered organisms
C42S
-
mutant enzyme with almost no activity in the reaction with H2 and oxidized benzyl viologen
C45S
-
mutants with about 5% of the wild-type activity in the reaction with H2 and oxidized benzyl viologen
C48S
-
mutant enzyme with almost no activity in the reaction with H2 and oxidized benzyl viologen
C73S
-
mutants with about 5% of the wild-type activity in the reaction with H2 and oxidized benzyl viologen
C76S
-
mutant enzyme with almost no activity in the reaction with H2 and oxidized benzyl viologen
C79S
-
mutants with about 5% of the wild-type activity in the reaction with H2 and oxidized benzyl viologen
C83S
-
mutant enzyme with approximately 10% of the activity of the wild-type enzyme in the reaction with H2 and oxidized benzyl viologen
additional information