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1.11.2.4: fatty-acid peroxygenase

This is an abbreviated version!
For detailed information about fatty-acid peroxygenase, go to the full flat file.

Word Map on EC 1.11.2.4

Reaction

fatty acid
+
H2O2
=
3- or 2-hydroxy fatty acid
+
H2O

Synonyms

alpha-fatty acid hydroxylase, CYP152A1, CYP152A2, CYP152B1, CYP505, cytochrome P450 monooxygenase, cytochrome P450BSbeta, fatty-acid hydroxylase, fatty-acid subterminal hydroxylase, hydrogen peroxide-dependent cytochrome P450BSbeta, hydrogen peroxide-dependent fatty acid alpha-hydroxylase, hydrogen peroxide-dependent peroxygenase cytochrome P450, P450 BM-3 peroxygenase 21B3, P450 peroxygenase, P450BSbeta, P450CLA, P450foxy, P450SPalpha, peroxygenase cytochrome P450, peroxygenase P450, peroxygenase P450SPalpha

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.2 Peroxygenases
                1.11.2.4 fatty-acid peroxygenase

Systematic Name

Systematic Name on EC 1.11.2.4 - fatty-acid peroxygenase

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SYSTEMATIC NAME
IUBMB Comments
fatty acid:hydroperoxide oxidoreductase (RH-hydroxylating)
A cytosolic heme-thiolate protein with sequence homology to P-450 monooxygenases. Unlike the latter, it needs neither NAD(P)H, dioxygen nor specific reductases for function. Enzymes of this type are produced by bacteria (e.g. Sphingomonas paucimobilis, Bacillus subtilis). Catalytic turnover rates are high compared with those of monooxygenation reactions as well as peroxide shunt reactions catalysed by the common P-450s. A model substrate is myristate, but other saturated and unsaturated fatty acids are also hydroxylated. Oxidizes the peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) and peroxygenates aromatic substrates in a fatty-acid-dependent reaction.