1.11.1.B10: D-ascorbate peroxidase
This is an abbreviated version!
For detailed information about D-ascorbate peroxidase, go to the full flat file.
Reaction
2 D-ascorbate + + 2 H+ = + + 2 H2O
Synonyms
CaO19.584, CCP2, D-erythroascorbate peroxidase, EAPX1, erythroascorbate peroxidase
ECTree
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General Information
General Information on EC 1.11.1.B10 - D-ascorbate peroxidase
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physiological function
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D-erythroascorbate peroxidase EAPX1 deficiency causes glutathione deprivation, leading to the accumulation of methylglyoxal and reactive oxygen species, and induction of cytochrome c peroxidase CCP1. CCP1/EAPX1 double disruptants show severe growth defects due to D-erythroascorbic acid and glutathione depletion because of pyruvate overaccumulation
physiological function
D-erythroascorbate peroxidase-deficient cells have remarkably increased intracellular reactive oxygen species and methylglyoxal independent of the intracellular D-erythroascorbate content, which leads to activation of catalase-peroxidase and cytochrome c peroxidase, resulting in defects in cell growth, viability, mitochondrial respiration, filamentation and virulence. EAPX1-deficient or EAPX1-overexpressing cells show more sensitivity or resistance against the exogenous H2O2 and menadione, respectively