1.11.1.9: glutathione peroxidase

This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.

Reaction

2 glutathione +

Synonyms

2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.9 glutathione peroxidase

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Results	in table
18	Activating Compound
1510	AA Sequence
12	Application
1	CAS Registry Number
29	Cloned(Commentary)
9	Crystallization (Commentary)
13419	Disease/ Diagnostics
27	Expression
20	General Information
7	General Stability
77	Inhibitors
4	kcat/KM [mM/s]
4	Ki Value [mM]
63	KM Value [mM]
90	Localization
62	Metals/Ions
52	Molecular Weight [Da]
122	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
228	Organism
2	Oxidation Stability
7	Pathway
25	PDB ID
20	pH Optimum
5	pH Range
7	pH Stability
4	pI Value
2	Posttranslational Modification
15	Protein Variants
39	Purification (Commentary)
3	Reaction
3	Reaction Type
199	Reference
269	Source Tissue
45	Specific Activity [micromol/min/mg]
8	Storage Stability
253	Substrates and Products (Substrate)
62	Subunits
216	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
5	Temperature Range [°C]
4	Temperature Stability [°C]
23	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 1.11.1.9 - glutathione peroxidase

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0 - 25

Rattus norvegicus

-

freezing the preparation with subsequent thawing with a gradual increase in temperature from 0°C to 25°C causes a 75% loss of the enzyme activity compared to the initial level

695719

100

Mammalia

-

complete inactivation

396605

30 - 70

Rattus norvegicus

-

glutathione peroxidase activity is retained after incubation at 30°C for 3.5 h and at 40°C for 1.5 h, an increase in the incubation temperature to 50°C and 70°C leads to inactivation of the enzyme within 1 h and 40 min, respectively

695719

40

Pseudoalteromonas sp. ANT506

W5ZSQ6

half-life 40 min

742024