1.11.1.9: glutathione peroxidase
This is an abbreviated version!
For detailed information about glutathione peroxidase, go to the full flat file.
Word Map on EC 1.11.1.9
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1.11.1.9
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dismutase
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catalase
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sod
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malondialdehyde
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necrosis
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thiobarbituric
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erythrocyte
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wistar
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tnf
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tbars
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glutathione-s-transferase
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s-transferase
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cholesterol
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reperfusion
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hippocampus
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ischemia
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myocardial
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selenite
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gssg
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triglyceride
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hepatotoxicity
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creatinine
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defenses
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aminotransferase
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caspase-3
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anti-oxidant
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bcl-2
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neuroprotective
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sacrificed
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albino
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cardiac
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selenoproteins
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alpha-tocopherol
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mn-sod
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2-related
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hepatoprotective
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streptozotocin
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acid-reactive
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melatonin
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dienes
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myeloperoxidase
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ccl4-induced
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8-ohdg
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uric
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analysis
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gavage
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medicine
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nephrotoxicity
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synthesis
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pro-oxidant
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peroxidases
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ccl4
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oxygenase-1
- 1.11.1.9
- dismutase
- catalase
- sod
- malondialdehyde
- necrosis
-
thiobarbituric
- erythrocyte
- wistar
- tnf
-
tbars
- glutathione-s-transferase
- s-transferase
- cholesterol
-
reperfusion
- hippocampus
- ischemia
- myocardial
- selenite
- gssg
- triglyceride
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hepatotoxicity
- creatinine
-
defenses
- aminotransferase
- caspase-3
-
anti-oxidant
- bcl-2
-
neuroprotective
-
sacrificed
-
albino
- cardiac
-
selenoproteins
- alpha-tocopherol
- mn-sod
-
2-related
-
hepatoprotective
- streptozotocin
-
acid-reactive
- melatonin
-
dienes
- myeloperoxidase
-
ccl4-induced
-
8-ohdg
-
uric
- analysis
-
gavage
- medicine
-
nephrotoxicity
- synthesis
-
pro-oxidant
- peroxidases
- ccl4
- oxygenase-1
Reaction
2 glutathione
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Synonyms
2-SeCD, 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate, 6P229, ADA-Te-OH, ARMEP24, AtGPX1, ATGPX3, c-GPx4, Cellular glutathione peroxidase, cgd3_460, cGPx, Cuticular glycoprotein GP29, DI29, ebselen, EGLP, Epididymis-specific glutathione peroxidase-like protein, Extracellular glutathione peroxidase, G-6137, Gastrointestinal glutathione peroxidase, glutathione peroxidase 1, glutathione peroxidase 2, glutathione peroxidase 3, glutathione peroxidase 4, glutathione peroxidase Gpx2, glutathione peroxidase Gpx3, glutathione peroxidase-1, glutathione peroxidase-2, glutathione peroxidase-3, glutathione peroxidase-4, glutathione-dependent peroxidase I, glutathione:hydrogen-peroxide oxidoreductase, GP30, GPRP, GPX, Gpx-1, GPx-2, GPx-3, GPx-4, GPx-5, GPx-6, GPx-7, GPx-8, GPX1, Gpx2, GPX3, GPx4, GPX5, GSH peroxidase, GSH-Px, GSHPx, GSHPx-GI, intracellular GpX, m-GPx4, Major androgen-regulated protein, Major surface antigen GP29, n-GPx4, Nt-SubC08, Odorant-metabolizing protein RY2D1, Os02g0664000, OsGPX5, peroxidase, glutathione, PGdx, pGPx, PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, nuclear form, phospholipid hydroperoxide Gpx, plasma glutathione peroxidase, prion protein Ure2, reduced glutathione peroxidase, Salt-associated protein, Se-GPx, Se-hGSTZ1-1, Se-scFv-B3, secreted GpX, SeGPx, selenium containing glutathione transferase zeta1-1, selenium-dependent glutathione peroxidase, selenium-glutathione peroxidase, seleno-dependent glutathione peroxidase 1, selenosubtilisin, snGPx, TcGPXI, TTHERM_00046090, TTHERM_00046110, TTHERM_01099010, Ure2
ECTree
1.11.1.9 glutathione peroxidaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 1.11.1.9 - glutathione peroxidase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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pGPx is expressed during bovine adipocyte differentiation, transcriptional control of pGPx in cattle might be carried out by C/EBPdelta
GPx-3 is detected at very low levels under basal conditions
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GPx is detected on the membranes of vacuoles situated in the gland's epithelial cells
GPx-2
GPx-6
highly expressed in pre-vitellogenic and mid-vitellogenic oocytes, while no expression is detected in late-vitellogenic oocytes
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GPx is detected in the tubulo-alveolar structures of the gland's parenchyma, in the apical part of secreting epithelial cells of the gland's alveoli, and in the vascular endothelium of blood vessels found in interstitial connective tissue
isozyme n-GPx-4 is specifically expressed in late spermatocytes
additional information
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GPX activity was significantly higher in HIV-positive than in HIV-negative subjects. When GPX activity is compared by HIV status and ARTuse, HIV-negative subjects have the lowest median, HIV-positive subjects not taking ART have an intermediate median (11% greater than that of HIV-negative subjects), and HIV-positive subjects taking ART have the highest median (21% higher than that of the HIV-positive subjects not taking ART)
highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
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potential for Gpx1 and Gpx2 redundancy in lymphatic tissue, but not in epithelial cells of the colon crypt or in the lamina propria, sub-mucosa, muscularis or serosa
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activity in erythrocytes from patients with non-small-cell lung cancer and small-cell lung cancer is slightly increased compared to healthy control group
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
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overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart
highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain
highest mRNA expression in pyloric ceca, followed by brain, heart and liver
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
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significant down-regulation of immunodetectable glutathione peroxidase proteins in remnant kidney in chronic renal failure, glutathione peroxidase activity is not significantly affected
highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain
highest mRNA expression in pyloric ceca, followed by brain, heart and liver
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396610, 396612, 396614, 396615, 396617, 396618, 396635, 396636, 396638, 396641, 396645, 685480, 688957, 695410, 695719, 726472
highest levels of transcripts in hepatopancreas, followed by a little lower expression in hemocytes and moderate expression in the tissues of brain, eyestalk, gill, intestine and muscle, with the lowest expression in the heart
specifically expressed in shrimp ovaries, but not in other tissues
highest mRNA expression in ovary, followed by pyloric caeca, heart, liver and brain
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the intrinsically low level of Gpx activity in the islets sets up the beta cell as an organelle particularly susceptible to oxidative stress secondary to high levels of glucose. Adenoviral overexpression of Gpx increases Gpx activity and protects islets against adverse effects of ribose
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expression is observed in the membranes of vacuoles contained in prostate secretions as well as in the endothelium of arterioles and venules
highest mRNA expression in ovary, followed by pyloric ceca, heart, liver and brain
highest mRNA expression in pyloric ceca, followed by brain, heart and liver
additional information
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GPX transcript is absent from both immature and mature oocytes
additional information
the mRNA is present throughout the nematode second stage juvenile and is particularly abundant in metabolically active tissues including the genital primordia
additional information
the mRNA is present throughout the nematode second stage juvenile and is particularly abundant in metabolically active tissues including the genital primordia
additional information
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the mRNA is present throughout the nematode second stage juvenile and is particularly abundant in metabolically active tissues including the genital primordia
additional information
in general, isoform Gpx4b mRNA expression exceeds that of isoform Gpx4a in all tissues with the exception of the pyloric caeca. The ratio of gpx4b/gpx4a is highest in ovary, and lowest in pyloric caeca
additional information
in general, isoform Gpx4b mRNA expression exceeds that of isoform Gpx4a in all tissues with the exception of the pyloric caeca. The ratio of gpx4b/gpx4a is highest in ovary, and lowest in pyloric caeca
additional information
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in general, isoform Gpx4b mRNA expression exceeds that of isoform Gpx4a in all tissues with the exception of the pyloric caeca. The ratio of gpx4b/gpx4a is highest in ovary, and lowest in pyloric caeca
additional information
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not detected in heart, brain, gut, muscle, epidermis, and testis
