1.11.1.8: iodide peroxidase
This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.
Word Map on EC 1.11.1.8
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1.11.1.8
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thyroglobulin
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tsh
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autoimmune
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hypothyroidism
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autoantibody
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thyroxin
-
women
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graves
-
tpoabs
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hashimoto
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thyrotropin
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thyroid-stimulating
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pregnancy
-
subclinical
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euthyroidism
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triiodothyronine
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goiter
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follicular
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overt
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thyrocytes
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anti-tpo
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antithyroid
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symporter
-
organification
-
trimester
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levothyroxine
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autoantigens
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thyroid-specific
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frtl-5
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guaiacol
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methimazole
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lactoperoxidase
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radioiodine
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propylthiouracil
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goitrous
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thyrotoxicosis
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antibody-negative
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multinodular
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analysis
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peroxidase-catalyzed
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hypothalamic-pituitary-thyroid
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ophthalmopathy
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gadas
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tsh-induced
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anti-thyroglobulin
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medicine
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thyroid-associated
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tsh-stimulated
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chloroperoxidase
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synthesis
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nodosum
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haloperoxidases
-
thyrotoxic
- 1.11.1.8
- thyroglobulin
- tsh
- autoimmune
- hypothyroidism
- autoantibody
- thyroxin
- women
- graves
-
tpoabs
- hashimoto
- thyrotropin
-
thyroid-stimulating
- pregnancy
-
subclinical
-
euthyroidism
- triiodothyronine
- goiter
-
follicular
-
overt
- thyrocytes
-
anti-tpo
-
antithyroid
-
symporter
-
organification
-
trimester
- levothyroxine
- autoantigens
-
thyroid-specific
-
frtl-5
- guaiacol
- methimazole
- lactoperoxidase
-
radioiodine
- propylthiouracil
-
goitrous
- thyrotoxicosis
-
antibody-negative
-
multinodular
- analysis
-
peroxidase-catalyzed
-
hypothalamic-pituitary-thyroid
-
ophthalmopathy
-
gadas
-
tsh-induced
-
anti-thyroglobulin
- medicine
-
thyroid-associated
-
tsh-stimulated
- chloroperoxidase
- synthesis
- nodosum
- haloperoxidases
-
thyrotoxic
Reaction
Synonyms
bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO
ECTree
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Substrates Products
Substrates Products on EC 1.11.1.8 - iodide peroxidase
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REACTION DIAGRAM
monoiodotyrosine + H2O2 + I-
monoiodotyrosine + diiodotyrosine + H2O
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90% diiodotyrosine, 6% monoiodotyrosine, determined using radioactive I-
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iodide + H2O2
iodine + H2O
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iodination and coupling reactions of proteins
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?
iodide + H2O2
iodine + H2O
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iodination and coupling reactions of proteins
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?
iodide + H2O2
iodine + H2O
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autoantigenin autoimmune thyroid disease
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?
iodide + H2O2
iodine + H2O
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iodination and coupling reactions of proteins
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?
iodide + H2O2
iodine + H2O
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highest activity if coupled with glucose-glucose oxidase reaction for H2O2 production
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?
iodide + H2O2
iodine + H2O
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iodination and coupling reactions of proteins
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?
iodide + H2O2
iodine + H2O
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iodination and coupling reactions of proteins
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?
monoiodotyrosine + diiodotyrosine + H2O
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ratio 1:4
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amino acids from TPO region 713-717 are the key residues, recognized by IDR/B-specific anti-TPO autoantibodies in autoimmune thyroid disease
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additional information
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several changes in ultracytochemical characteristics of the enzyme are associated with thyroid disease
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additional information
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H353, D358, S359 and R361 are amino acid residues contributing to the binding of anti-TPO autoantibodies in the immunodominant regions
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additional information
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protein radical formation on thyroid peroxidase during turnover
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additional information
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hypothyroid dwarfism due to the missense mutation R479C of the thyroid peroxidase gene in the mouse
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