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1.11.1.8: iodide peroxidase

This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.

Word Map on EC 1.11.1.8

Reaction

2 iodide +

H2O2
+ 2 H+ =
diiodine
 + 2 H2O

Synonyms

bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.8 iodide peroxidase

Inhibitors

Inhibitors on EC 1.11.1.8 - iodide peroxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-Methyl-2-mercaptoimidazole
-
competitive with iodide
2,2',4,4'-tetrahydroxybenzophenone
2-mercaptobenzothiazole
-
3,4,5-hydroxybenzoic acid propyl ester
-
mixed type inhibition
3-methylcholanthrene
-
-
6-Propyl-2-thiouracil
-
amino-1,2,4-triazole
-
-
Aminotriazole
apigenin
uncompetitive, IC50 value 0.406 mg/ml
arsenic trioxide
azide
benzhydrol
-
reduces the enzyme activity by about 30% from 0.01 to 0.1 mM
benzo(e)pyrene
-
-
benzo(k)fluoranthene
-
-
benzophenone
-
-
benzophenone 2
-
inactivation is prevented by iodideone of the most potent inhibitors of TPO
bisphenol A
-
-
catechin
competitive, IC50 value 0.078 mg/ml
chlorogenic acid
noncompetitive
cyanide
cysteine
-
complete inhibition at 0.05 mM, reversible by increasing I- concentration
F21388
-
-
fisetin
-
-
genistein
glutathione
heptachlor
-
weakly inhibits the enzyme activity by about 50% at 0.01 mM
histidine
-
-
Iodide
-
above 0.1 mM at pH 5, no inhibition at pH 7
kaempferol
mearnsitrin
-
IC50: 0.00197 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter
methimazol
-
-
Methimazole
methionine
-
complete inhibition at 0.05 mM, reversible by increasing I- concentration
morin
-
-
myricetin
-
non competitive with I-
Myricitrin
-
IC50: 0.00188 mM. Flavonoid from aqueous partition of Myrcia uniflora. Indiscriminated consumption of Myrcia uniflora pharmaceutical products allied to the nutritional deficiency of iodine might contribute to the development of hypothyroidism and goiter
naringenin
-
non competitive with I-, competitive with H2O2
p-Aminobenzoic acid
-
-
parsley ethanol extract
-
-
perfluorooctane sulfonate
-
-
Perfluorooctanoic acid
-
slight inhibition at 0.01 mM
phenylalanine
-
-
propylthiouracil
pyrene
-
-
quercetin
reduced glutathione
-
presence of 0.1 ppm minimally affects enzyme activity. Presence of 0.1 ppm arsenic trioxide plus 0.1 ppm reduced glutathione leads to complete inhibition
resorcinol
rosmarinic acid
competitive, rutin and rosmarinic acid act additively
rutin
sinapinic acid
competitive, IC50 value 0.084 mg/ml
sulfathiazole
-
-
sunitinib
-
sunitinib is a tyrosine kinase inhibitor with antitumor and antiangiogenic effects. Its antithyroid effect appears to be inhibition of peroxidase
thiocyanate
-
competitive with iodide
thiouracil
Thiourea
TR1.9 autoantibody
preferentially binds the TPO monomer and inhibits the catalytic activity
-
tryptophan
-
complete inhibition at 0.05 mM, reversible by increasing I- concentration
tyrosine
-
-
additional information
-