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1.11.1.8: iodide peroxidase

This is an abbreviated version!
For detailed information about iodide peroxidase, go to the full flat file.

Word Map on EC 1.11.1.8

Reaction

2 iodide +

H2O2
+ 2 H+ =
diiodine
 + 2 H2O

Synonyms

bromoperoxidase, high-molecular weight-thyroid peroxidase, HMW-TPO, hrTPO, hTPO, iodide peroxidase-tyrosine iodinase, iodinase, iodoperoxidase (heme type), thyroid peroxidase, thyroperoxidase, TPO, TPOX, TPQ, tyrosine iodinase, vanadium bromoperoxidase, vBPO

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.8 iodide peroxidase

Engineering

Engineering on EC 1.11.1.8 - iodide peroxidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C808R
natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type
D358A
-
mutation at position 358 led to a loss of the binding of human anti-TPO autoantibodies as efficient as a mutation of the entire region 353–363
D574/L575del
-
expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin
G387R
natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type
G533C
-
expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin
G771R
-
expressed to some extent on the cell surface, prolongation in kinetics, increasing interaction with calnexin
P499L
natural missense mutation, mutant shows higher Km values and lower reaction efficiencies thna wild-type
Q446H
-
the mutation is associated with the occurrence of congenital hypothyroidism
W527C
-
the mutation is associated with the occurrence of congenital hypothyroidism
W873X
-
the mutation is associated with the occurrence of congenital hypothyroidism
R479C
-
a novel hypothyroid dwarfism due to the missense mutation R479C of the thyroid peroxidase gene in the mouse
additional information