1.11.1.28: lipoyl-dependent peroxiredoxin
This is an abbreviated version!
For detailed information about lipoyl-dependent peroxiredoxin, go to the full flat file.
Word Map on EC 1.11.1.28
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1.11.1.28
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peroxiredoxins
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xanthomonas
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campestris
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tert-butyl
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phaseoli
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tbooh
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cys-based
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xylella
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peroxidatic
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cumene
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medicine
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thiol-dependent
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fastidiosa
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glutaredoxins
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osmcs
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peroxide-sensing
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sulfenic
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lipoylated
- 1.11.1.28
- peroxiredoxins
- xanthomonas
- campestris
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tert-butyl
- phaseoli
-
tbooh
-
cys-based
- xylella
-
peroxidatic
- cumene
- medicine
-
thiol-dependent
- fastidiosa
- glutaredoxins
-
osmcs
-
peroxide-sensing
-
sulfenic
-
lipoylated
Reaction
Synonyms
AhpC, AhpCD, AhpD, ahpD1, ahpD2, alkyl hydroperoxide reductase, alkyl hydroperoxide reductase subunit C, EC 1.11.1.15, MfOhr, Ohr, Organic hydroperoxide resistance, organic hydroperoxide resistance protein, peroxiredoxin AhpC, peroxiredoxin AhpD
ECTree
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General Information
General Information on EC 1.11.1.28 - lipoyl-dependent peroxiredoxin
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drug target
malfunction
physiological function
immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract. AhpC as a potential vaccine candidate against inhabitation or infection of Fusobacterium nucleatum in the intestinal tract, which could provide a practical strategy for the prevention of colorectal cancer associated with Fn infection
drug target
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immunization with alkyl hydroperoxide reductase subunit C reduces Fusobacterium nucleatum load in the intestinal tract. AhpC as a potential vaccine candidate against inhabitation or infection of Fusobacterium nucleatum in the intestinal tract, which could provide a practical strategy for the prevention of colorectal cancer associated with Fn infection
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DELTAahpCD strain is notably more sensitive than its parent strain to hydrogen peroxide (H2O2) but not to organic peroxides (tertbutyl hydroperoxide and cumene hydroperoxide), in the early log phase. The catalase activity of the DELTAahpCD strain is affected at a relatively low level of H2O2 stress. The DELTAahpCD strain induces a reduced number of stem nodules in Sesbania rostrata with lowering of nitrogenase activity
malfunction
DELTAahpD1DELTAahpD2 mutants exhibit significantly decreased resistance to adverse stress conditions and increased accumulation of reactive oxygen species (ROS)
malfunction
DELTAohr strain presents a reduced capacity to grow in the presence of either artificial (cumene hydroperoxide and tert-butyl hydroperoxide) or fatty acid hydroperoxides compared with the wild type
malfunction
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DELTAahpCD strain is notably more sensitive than its parent strain to hydrogen peroxide (H2O2) but not to organic peroxides (tertbutyl hydroperoxide and cumene hydroperoxide), in the early log phase. The catalase activity of the DELTAahpCD strain is affected at a relatively low level of H2O2 stress. The DELTAahpCD strain induces a reduced number of stem nodules in Sesbania rostrata with lowering of nitrogenase activity
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malfunction
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DELTAahpD1DELTAahpD2 mutants exhibit significantly decreased resistance to adverse stress conditions and increased accumulation of reactive oxygen species (ROS)
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malfunction
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DELTAohr strain presents a reduced capacity to grow in the presence of either artificial (cumene hydroperoxide and tert-butyl hydroperoxide) or fatty acid hydroperoxides compared with the wild type
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AhpC is a critical element of the antioxidant defense system of Mycobacterium tuberculosis
physiological function
AhpD is a critical element of the antioxidant defense system of Mycobacterium tuberculosis
physiological function
Mycobacterium tuberculosis persists in host macrophages, where it faces a nutrient-poor environment and is exposed to oxidative and nitrosative stress. The enzyme defends Mycobacterium tuberculosis against oxidative stress
physiological function
the enzyme provides antioxidant protection
physiological function
AhpCD is required for resistance to low concentrations of H2O2 in the free-living stage and during symbiosis with Sesbania rostrata. AhpCD contributes to H2O2 resistance at the early log phase of Azorhizobium caulinodans growth. ahpCD is required for stem nodulation but not root nodulation in Sesbania rostrata
physiological function
AhpD acts as a backup of thioredoxin to provide reducing power for peroxidase
physiological function
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alkyl hydroperoxide reductase subunit C acquires chaperone activity under heat stress. High-molecular-weight oligomer formation and the chaperone-like activity of oxidized AhpC depend on the incubation temperature and the period of incubation
physiological function
Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite
physiological function
the ahpD gene is more involved in defences against H2O2 than in detoxifying alkyl hydroperoxide. It plays an important role in hydrogen peroxide-induced oxidative stress response
physiological function
the enzyme is involved in the Pseudomonas aeruginosa response to fatty acid hydroperoxides and to peroxynitrite. Therefore, Ohr plays central roles in the bacterial response to two hydroperoxides that are at the host-pathogen interface
physiological function
the enzyme is important for H2O2 detoxification in vitro and also critical for symbiosis of Azorhizobium caulinodans with Sesbania rostrate. The enzyme is required for stem nodulation and nitrogenase activity
physiological function
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AhpCD is required for resistance to low concentrations of H2O2 in the free-living stage and during symbiosis with Sesbania rostrata. AhpCD contributes to H2O2 resistance at the early log phase of Azorhizobium caulinodans growth. ahpCD is required for stem nodulation but not root nodulation in Sesbania rostrata
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physiological function
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Ohr plays a central role in bacterial responses against fatty acid hydroperoxides and peroxynitrite
-
physiological function
-
the ahpD gene is more involved in defences against H2O2 than in detoxifying alkyl hydroperoxide. It plays an important role in hydrogen peroxide-induced oxidative stress response
-
physiological function
-
AhpD acts as a backup of thioredoxin to provide reducing power for peroxidase
-
physiological function
-
Mycobacterium tuberculosis persists in host macrophages, where it faces a nutrient-poor environment and is exposed to oxidative and nitrosative stress. The enzyme defends Mycobacterium tuberculosis against oxidative stress
-
physiological function
-
the enzyme provides antioxidant protection
-
physiological function
-
AhpD is a critical element of the antioxidant defense system of Mycobacterium tuberculosis
-
physiological function
-
AhpC is a critical element of the antioxidant defense system of Mycobacterium tuberculosis
-
physiological function
-
the enzyme is important for H2O2 detoxification in vitro and also critical for symbiosis of Azorhizobium caulinodans with Sesbania rostrate. The enzyme is required for stem nodulation and nitrogenase activity
-
physiological function
-
the enzyme is involved in the Pseudomonas aeruginosa response to fatty acid hydroperoxides and to peroxynitrite. Therefore, Ohr plays central roles in the bacterial response to two hydroperoxides that are at the host-pathogen interface
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