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1.11.1.27: glutathione-dependent peroxiredoxin

This is an abbreviated version!
For detailed information about glutathione-dependent peroxiredoxin, go to the full flat file.

Word Map on EC 1.11.1.27

Reaction

2 glutathione +

ROOH
=
glutathione disulfide
+
H2O
+
ROH

Synonyms

1-Cys peroxiredoxin, 1-Cys Prdx, 1-Cys Prx, 1-CysPrx, 2-Cys peroxiredoxin, 2-Cys peroxiredoxin TPx-1, EC 1.11.1.15, glutathione peroxidase, GPX, HI0572, peroxiredoxin 6, peroxiredoxin II, peroxiredoxin VI, Pf1-Cys-Prx, PGdx, Prdx6, Prx1, Prx3, Prx6, TPx-1

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.27 glutathione-dependent peroxiredoxin

Reference

Reference on EC 1.11.1.27 - glutathione-dependent peroxiredoxin

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Merkulova, M.I.; Shuvaeva, T.M.; Radchenko, V.V.; Yanin, B.A.; Bondar, A.A.; Sofin, A.D.; Lipkin, V.M.
Recombinant human peroxiredoxin VI: preparation and protective properties in vitro
Biochemistry
67
1235-1239
2002
Homo sapiens (P30041), Homo sapiens
Manually annotated by BRENDA team
Rouhier, N.; Jacquot, J.P.
Molecular and catalytic properties of a peroxiredoxin-glutaredoxin hybrid from Neisseria meningitidis
FEBS Lett.
554
149-153
2003
Neisseria meningitidis
Manually annotated by BRENDA team
Kang, S.W.; Baines, I.C.; Rhee, S.G.
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine
J. Biol. Chem.
273
6303-6311
1998
Homo sapiens (P30041)
Manually annotated by BRENDA team
Rouhier, N.; Gama, F.; Wingsle, G.; Gelhaye, E.; Gans, P.; Jacquot, J.P.
Engineering functional artificial hybrid proteins between poplar peroxiredoxin II and glutaredoxin or thioredoxin
Biochem. Biophys. Res. Commun.
341
1300-1308
2006
Populus tremula x Populus tremuloides (Q8S3L0)
Manually annotated by BRENDA team
Kawazu, S.; Ikenoue, N.; Takemae, H.; Komaki-Yasuda, K.; Kano, S.
Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparum
FEBS J.
272
1784-1791
2005
Plasmodium falciparum
Manually annotated by BRENDA team
Manevich, Y.; Fisher, A.B.
Peroxiredoxin 6, a 1-Cys peroxiredoxin, functions in antioxidant defense and lung phospholipid metabolism
Free Radic. Biol. Med.
38
1422-1432
2005
Mus musculus (O08709), Rattus norvegicus (O35244), Bos taurus (O77834), Homo sapiens (P30041), Sus scrofa (Q9TSX9)
Manually annotated by BRENDA team
Yano, K.; Komaki-Yasuda, K.; Tsuboi, T.; Torii, M.; Kano, S.; Kawazu, S.
2-Cys Peroxiredoxin TPx-1 is involved in gametocyte development in Plasmodium berghei
Mol. Biochem. Parasitol.
148
44-51
2006
Plasmodium berghei
Manually annotated by BRENDA team
Manevich, Y.; Shuvaeva, T.; Dodia, C.; Kazi, A.; Feinstein, S.I.; Fisher, A.B.
Binding of peroxiredoxin 6 to substrate determines differential phospholipid hydroperoxide peroxidase and phospholipase A(2) activities
Arch. Biochem. Biophys.
485
139-149
2009
Rattus norvegicus (O35244)
Manually annotated by BRENDA team
Roede, J.R.; Carbone, D.L.; Doorn, J.A.; Kirichenko, O.V.; Reigan, P.; Petersen, D.R.
In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal
Chem. Res. Toxicol.
21
2289-2299
2008
Rattus norvegicus
Manually annotated by BRENDA team
Greetham, D.; Grant, C.M.
Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo
Mol. Cell. Biol.
29
3229-3240
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fisher, A.B.
Peroxiredoxin 6: A bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities
Antioxid. Redox Signal.
15
831-844
2010
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Pauwels, F.; Vergauwen, B.; Vanrobaeys, F.; Devreese, B.; Van Beeumen, J.J.
Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity
J. Biol. Chem.
278
16658-16666
2003
Haemophilus influenzae (P44758), Haemophilus influenzae ATCC 51907 (P44758)
Manually annotated by BRENDA team
Lim, J.G.; Bang, Y.J.; Choi, S.H.
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation
J. Biol. Chem.
289
36263-36274
2014
Vibrio vulnificus (ADV89163), Vibrio vulnificus MO6-24/O (ADV89163)
Manually annotated by BRENDA team
Manevich, Y.; Feinstein, S.I.; Fisher, A.B.
Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST
Proc. Natl. Acad. Sci. USA
101
3780-3785
2004
Bos taurus
Manually annotated by BRENDA team
Park, K.R.; Yun, H.M.; Yeo, I.J.; Cho, S.; Hong, J.T.; Jeong, Y.S.
Peroxiredoxin 6 inhibits osteogenic differentiation and bone formation through human dental pulp stem cells and induces delayed bone development
Antioxid. Redox Signal.
30
1969-1982
2019
Homo sapiens (P30041)
Manually annotated by BRENDA team
Arevalo, J.A.; Vazquez-Medina, J.P.
The role of peroxiredoxin 6 in cell signaling
Antioxidants (Basel)
7
172
2018
Mus musculus (O08709), Homo sapiens (P30041)
Manually annotated by BRENDA team
Shahnaj, S.; Chowhan, R.K.; Meetei, P.A.; Kakchingtabam, P.; Herojit Singh, K.; Rajendrakumar Singh, L.; Nongdam, P.; Fisher, A.B.; Rahaman, H.
Hyperoxidation of peroxiredoxin 6 induces alteration from dimeric to oligomeric state
Antioxidants (Basel)
8
33
2019
Rattus norvegicus (O35244)
Manually annotated by BRENDA team
Fisher, A.B.
Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling
Arch. Biochem. Biophys.
617
68-83
2017
Mus musculus (O08709)
Manually annotated by BRENDA team
Wang, L.L.; Lu, S.Y.; Hu, P.; Fu, B.Q.; Li, Y.S.; Zhai, F.F.; Ju, D.D.; Zhang, S.J.; Su, B.; Zhou, Y.; Liu, Z.S.; Ren, H.L.
Construction and activity analyses of single functional mouse peroxiredoxin 6 (Prdx6)
J. Vet. Res.
63
99-105
2019
Mus musculus (O08709)
Manually annotated by BRENDA team
Lopez Grueso, M.J.; Tarradas Valero, R.M.; Carmona-Hidalgo, B.; Lagal Ruiz, D.J.; Peinado, J.; McDonagh, B.; Requejo Aguilar, R.; Barcena Ruiz, J.A.; Padilla Pena, C.A.
Peroxiredoxin 6 down-regulation induces metabolic remodeling and cell cycle arrest in HepG2 cells
Antioxidants (Basel)
8
505
2019
Homo sapiens (P30041)
Manually annotated by BRENDA team
Pankiewicz, J.E.; Diaz, J.R.; Marta-Ariza, M.; Lizi?czyk, A.M.; Franco, L.A.; Sadowski, M.J.
Peroxiredoxin 6 mediates protective function of astrocytes in Abeta proteostasis
Mol. Neurodegener.
15
50
2020
Mus musculus
Manually annotated by BRENDA team
Chen, C.; Gong, L.; Liu, X.; Zhu, T.; Zhou, W.; Kong, L.; Luo, J.
Identification of peroxiredoxin 6 as a direct target of withangulatin A by quantitative chemical proteomics in non-small cell lung cancer
Redox Biol.
46
102130
2021
Homo sapiens (P30041)
Manually annotated by BRENDA team
Chowhan, R.K.; Rahaman, H.; Singh, L.R.
Structural basis of peroxidase catalytic cycle of human Prdx6
Sci. Rep.
10
17416
2020
Homo sapiens (P30041)
Manually annotated by BRENDA team
Chowhan, R.K.; Hotumalani, S.; Rahaman, H.; Singh, L.R.
pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature
Sci. Rep.
11
9657
2021
Homo sapiens (P30041)
Manually annotated by BRENDA team