1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase

This is an abbreviated version!
For detailed information about (S)-2-hydroxypropylphosphonic acid epoxidase, go to the full flat file.

Word Map on EC 1.11.1.23

Reaction

(S)-2-hydroxypropylphosphonate
+
H2O2
=
(1R,2S)-1,2-epoxypropylphosphonate
+ 2 H2O

Synonyms

(S)-2-HPP epoxidase, (S)-2-hydroxypropylphosphonic acid epoxidase, (S-HPP) epoxidase, 2-hydroxypropylphosphonic acid epoxidase, fom4, fosfomycin-producing epoxidase, HPP epoxidase, HppE, Ps-HppE

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase

Systematic Name

Systematic Name on EC 1.11.1.23 - (S)-2-hydroxypropylphosphonic acid epoxidase

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SYSTEMATIC NAME
IUBMB Comments
(S)-2-hydroxypropylphosphonate:hydrogen peroxide epoxidase
This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7].