1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase

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For detailed information about (S)-2-hydroxypropylphosphonic acid epoxidase, go to the full flat file.

Reaction

Synonyms

(S)-2-HPP epoxidase, (S)-2-hydroxypropylphosphonate epoxidase, (S)-2-hydroxypropylphosphonic acid epoxidase, (S-HPP) epoxidase, 2-hydroxypropylphosphonic acid epoxidase, EC 1.14.19.7, fom4, fosfomycin-producing epoxidase, HPP epoxidase, HppE, Ps-HppE

ECTree

     1 Oxidoreductases

         1.11 Acting on a peroxide as acceptor

             1.11.1 Peroxidases

                1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidase

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Results	in table
25	AA Sequence
2	Application
1	CAS Registry Number
7	Cloned(Commentary)
16	Cofactor
3	Crystallization (Commentary)
5	Inhibitors
16	Metals/Ions
12	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
24	Organism
4	Pathway
16	PDB ID
1	pH Optimum
2	Posttranslational Modification
7	Protein Variants
5	Purification (Commentary)
5	Reaction
24	Reference
59	Substrates and Products (Substrate)
10	Subunits
25	Synonyms
1	Systematic Name
1	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.11.1.23 - (S)-2-hydroxypropylphosphonic acid epoxidase

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SYSTEMATIC NAME

IUBMB Comments

(S)-2-hydroxypropylphosphonate:hydrogen peroxide epoxidase

This is the last enzyme in the biosynthetic pathway of fosfomycin, a broad-spectrum antibiotic produced by certain Streptomyces species. Contains non heme iron that forms a iron(IV)-oxo (ferryl) complex with hydrogen peroxide, which functions as a proton abstractor from the substrate [7].