1.11.1.23: (S)-2-hydroxypropylphosphonic acid epoxidase
This is an abbreviated version!
For detailed information about (S)-2-hydroxypropylphosphonic acid epoxidase, go to the full flat file.
Word Map on EC 1.11.1.23
Reaction
Synonyms
(S)-2-HPP epoxidase, (S)-2-hydroxypropylphosphonate epoxidase, (S)-2-hydroxypropylphosphonic acid epoxidase, (S-HPP) epoxidase, 2-hydroxypropylphosphonic acid epoxidase, EC 1.14.19.7, fom4, fosfomycin-producing epoxidase, HPP epoxidase, HppE, Ps-HppE
ECTree
1.11.1.23 (S)-2-hydroxypropylphosphonic acid epoxidaseAdvanced search results
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Engineering on EC 1.11.1.23 - (S)-2-hydroxypropylphosphonic acid epoxidase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E142A
complete loss of enzymatic activity in vivo and in vitro, 2.1% of the active site iron as compared to wild-type enzyme, no self-hydroxylation at Tyr105
F182A
the variant favors trans-fosfomycin production from (S)-2-hydroxypropylphosphonate
H138A
inactive in vivo, but in vitro it retains 27% of the active site iron and nearly 20% of the wild-type activity, limited self-hydroxylation (at Tyr105)
H180A
complete loss of enzymatic activity in vivo and in vitro, 5.8% of the active site iron as compared to wild-type enzyme, no self-hydroxylation at Tyr105
Y102F
mutant maintains 60% of the activity of the wild-type enzyme
Y103F
mutant maintains 60% of the activity of the wild-type enzyme
