(S)-2-hydroxypropylphosphonic acid epoxidase

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Word Map on EC


+ 2 H2O


(S)-2-HPP epoxidase, (S)-2-hydroxypropylphosphonic acid epoxidase, (S-HPP) epoxidase, 2-hydroxypropylphosphonic acid epoxidase, fom4, fosfomycin-producing epoxidase, HPP epoxidase, HppE, Ps-HppE


     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
       (S)-2-hydroxypropylphosphonic acid epoxidase


Crystallization on EC - (S)-2-hydroxypropylphosphonic acid epoxidase

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crystal structures of holoenzyme and the complex with fosfomycin are determined and reveal a two-domain combination and Zn2+ in the active site
hanging drop vapour diffusion method, six X-ray structures of this enzyme: the apoenzyme at 2.0 A resolution, a native Fe2+-bound form at 2.4 A resolution; a tris(hydroxymethyl)aminomethane-Co2+-enzyme complex structure at 1.8 A resolution, a substrate-Co2+-enzyme complex structure at 2.5 A resolution; and two substrate-Fe2+-enzyme complexes at 2.1 and 2.3 A resolution
vapour diffusion method. The hexagonal form displays symmetry consistent with space group P6(1/5)22 and unit-cell parameters a = 86.44, c = 221.56 A, gamma = 120