1.11.1.19: dye decolorizing peroxidase

This is an abbreviated version, for detailed information about dye decolorizing peroxidase, go to the full flat file.

Reaction

Reactive Blue 5
+ 2 H2O2 =
Phthalate
+
2,2'-disulfonyl azobenzene
+
3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate
+ 2 H2O

Synonyms

AnaPX, dye-decolorizing peroxidase, DyP, DyP I, DyP II, DyP-I, DyP-type peroxidase, DyP1, DyP2, DyP3, EfeB, LiP BA45, LiP-SN, manganese-independent peroxidase I, manganese-independent peroxidase II, TT1485, tyrA, YcdB, YfeX, YwbN

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.19 dye decolorizing peroxidase

Inhibitors

Inhibitors on EC 1.11.1.19 - dye decolorizing peroxidase

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
55% residual activity at 1 mM
Ba2+
-
about 85% inhibition at 1 mM
Ca2+
T1SP91;
84.7% residual activity at 5 mM
Cd2+
-
complete inhibition at 1 mM
Co2+
-
about 56% inhibition at 1 mM
diethyl dicarbonate
less than 50% inhibition at 50 mM
dithiothreitol
-
81% residual activity at 1 mM
Fe2+
AnaPX is highly sensitive to Fe2+ (98.8% inhibition at 5 mM)
Hg2+
-
complete inhibition at 1 mM
hydroxylamine
-
25% residual activity at 2 mM
KCN
AnaPX shows very low sensitivity to KCN which causes only 9% and 14% inhibition of the activity at 1 and 10 mM, respectively
L-cystine
-
25% residual activity at 2 mM
Li+
T1SP91;
87% residual activity at 5 mM
NaN3
AnaPX is highly sensitive to NaN3 (82% inhibition at 10 mM)
phenylhydrazine
AnaPX is highly sensitive to the suicide substrate phenylhydrazine (complete inhibition at 1 mM)
potassium cyanide
Sodium azide
additional information
the enzyme is not sensitive to the prototypical catalase inhibitor 3-amino-1,2,4,-triazole in the presence of ascorbic acid (1.0 mM), metal chelating and sulfhydryl reagents do not significantly affect activity
-