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1.11.1.18: bromide peroxidase

This is an abbreviated version!
For detailed information about bromide peroxidase, go to the full flat file.

Word Map on EC 1.11.1.18

Reaction

RH
+
HBr
+
H2O2
=
RBr
+ 2 H2O

Synonyms

apobromoperoxidase I, BPO, BPO 1, BPO 2, BPO I, BPO-A1, BPO-A2, BPO1, bpoA1, bromooperoxidase, bromoperoxidase, bromoperoxidase A2, bromoperoxidase I, bromoperoxidase II, bromoperoxidase-catalase, BrPO, CoVBPO, CVBPO, EC 1.11.1.10, haeme-thiolate peroxidase, HAP phytase, metal-free bromoperoxidase, More, non-haem bromoperoxidase, non-haem bromoperoxidase BPO 1, non-haem bromoperoxidase BPO 2, non-haem bromoperoxidase BPO-A2, non-heme haloperoxidases, non-heme-type bromoperoxidase, nonhaem-type bromoperoxidase BPO 1a, nonhaem-type bromoperoxidase BPO 1b, nonhaem-type bromoperoxidase BPO 3, nonheme bromoperoxidase, nVBPO, perhydrolase, rVBPO, St-Phy, sVBPO, V-BPO, V-BrPO, V-containing-haloperoxidase, vanadate haloperoxidase, vanadate-dependent bromoperoxidase I, vanadium bromoperoxidase, vanadium containing bromoperoxidase, vanadium-bromoperoxidase, vanadium-containing bromoperoxidase, vanadium-dependent bromoperoxidase, vanadium-dependent bromoperoxidase 2, vanadium-dependent haloperoxidase, vanadium-dependent peroxidase, vBPO, VBPO1, VBPO2, VBrPO, VBrPO(AnI), VBrPO(AnII)

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.18 bromide peroxidase

Engineering

Engineering on EC 1.11.1.18 - bromide peroxidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H480A
results in the loss of the ability to efficiently oxidize bromide, but retains the ability to oxidize iodide
R397W
-
the mutant shows a different behaviour on bromide binding compared to the wild type enzyme, (the bromide is missing the hydrogen-binding interaction that held it in the active site of the wild type enzyme)
R379F
increase in affinity for Br-, enables the mutant to oxidize Cl-, decrease in affinity for I-
R379H
decrease in affinity for Br-
D229A
-
inactive mutant protein
H258Q
-
inactive mutant protein
S97A
-
inactive mutant protein
S97C
-
mutant with very low residual activity
additional information