1.11.1.13: manganese peroxidase

This is an abbreviated version!
For detailed information about manganese peroxidase, go to the full flat file.

Word Map on EC 1.11.1.13

Reaction

2 Mn(II) + 2 H+ +

H2O2
= 2 Mn(III) + 2 H2O

Synonyms

hybrid Mn-peroxidase, L-MnP, LeMnP2, manganese peroxidase, manganese-dependent peroxidase, Mn-dependent (NADH-oxidizing) peroxidase, Mn2+: hydrogen peroxide oxidoreductase, Mn2+:hydrogen peroxide oxidoreductase, MnP, MnP 1, MnP II, MnP-GY, MnP-PGY, mnp1, MnP2, MnP3, MnP6, MP, multifunctional manganese peroxidase, Nf b19 MNP2, peroxidase, manganese, peroxidase-M2

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.13 manganese peroxidase

Inhibitors

Inhibitors on EC 1.11.1.13 - manganese peroxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
inhibits competitive Mn(III)-malonate formation
2-mercaptoethanol
-
5 mM, about 60% inhibition
acetate
AgNO3
-
5 mM, about 60% inhibition
ascorbic acid
beta-mercaptoethanol
-
2 mM, complete inhibition
CaCl2
-
5 mM, about 20% inhibition
catalase
-
Cd2+
-
competitive inhibitor to Mn2+, uncompetitive to H2O2, reversibly inhibits oxidation of Mn2+ and Mn3+-mediated oxidation of 2,6-dimethoxyphenol, but not oxidation of phenols in absence of Mn2+, Cd2+ inhibits reduction of compound I and II by Mn2+ at pH 4.5 and binds at the Mn2+-binding site, kinetics of inhibition
cellobionate
-
inhibits competitive Mn(III)-malonate formation
cysteine
-
decolorization of bromocresol purple
diphosphate
ethylhydrazine
-
time-dependent inactivation via delta-meso-ethylheme adduct at pH 7.0, slightly stimulated by Co2+
Eu3+
-
competitive inhibitor to Mn2+
methylhydrazine
-
slow inactivation in presence of H2O2, concentration- and time-dependent, slightly stimulated by Co2+
N-bromosuccinimide
-
-
N-ethyl-5-phenylisoxazolium 3'-sulfonate
-
1 mM, 28% inhibition
Na+
-
no significant effect at 1.0 mM, inhibition at 10 mM concentration
nitrilotriacetate
-
inhibits competitive Mn(III)-malonate formation
Pb(NO3)2
-
5 mM, about 80% inhibition
Pc reducer
-
the activity of manganese peroxidase is inhibited by Pc reducer at concentrations higher than 0.2 mg/ml
-
phenyldiazene
-
concentration-dependent inactivation
phenylhydrazine
-
rapid inactivation, concentration-dependent, no heme adducts detectable, inactivation is slightly stimulated by Co2+
SDS
-
partial inhibition
selenium
-
-
Sm3+
-
competitive inhibitor to Mn2+
Sodium metavanadate
-
partially inhibits only peroxidase activity against veratryl alcohol
Superoxide dismutase
-
tetramethylethylenediamine
-
5 mM, about 50% inhibition
Thiourea
-
partial inhibition
additional information
-