manganese peroxidase

This is an abbreviated version!
For detailed information about manganese peroxidase, go to the full flat file.

Word Map on EC


2 Mn(II) + 2 H+ +

= 2 Mn(III) + 2 H2O


hybrid Mn-peroxidase, L-MnP, LeMnP2, manganese peroxidase, manganese-dependent peroxidase, Mn-dependent (NADH-oxidizing) peroxidase, Mn2+: hydrogen peroxide oxidoreductase, Mn2+:hydrogen peroxide oxidoreductase, MnP, MnP 1, MnP II, MnP-GY, MnP-PGY, mnp1, MnP2, MnP3, MnP6, MP, multifunctional manganese peroxidase, Nf b19 MNP2, peroxidase, manganese, peroxidase-M2


     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
       manganese peroxidase

General Stability

General Stability on EC - manganese peroxidase

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calcium stabilizes
CHAPS stabilizes
complete loss of activity after 1 h in 2 mM KCN
enzyme is more stable in carbon-limited cultures than in nitrogen-limited cultures
enzyme is very stable when the molar concentration of H2O2 is 10times of the concentration of the enzyme. When the H2O2 concentration is 250fold and 1000fold of the MnP concentration, the MnP activity decreases by 14% and 45%, respectively, in the first 15 min and remains the same thereafter. When the H2O2 concentration is 5000times of the enzyme concentration, the enzyme activity rapidly decreases in 30 min and then continues to decrease, but at a slower rate
enzyme retains more than 60% of the initial activity after exposure to 10 mM hydrogen peroxide for 5 min at 37°C
heat-inactivated protein, 100°C for 5 min, regains 80% of original activity by storage at 0°C for 1 h
Mn2+ and bovine serum albumin stabilize
no inactivation after 5 h in 50 mM Na-tartrate buffer, pH 4.5, with 2 mM nitrilotriacetate, 0.5 mM iodoacetamide or 2 mM PMSF
prolonged dialysis inactivates
stable to lyophilization