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1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.12

Reaction

2 glutathione +

a hydroperoxy-fatty-acyl-[lipid]
=
glutathione disulfide
 +
a hydroxy-fatty-acyl-[lipid]
 +
H2O

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

Source Tissue

Source Tissue on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
knockdown of GPx-4 by small interfering RNA technique in a human ovarian cancer cell line significantly enhances the cytotoxic effect of docosahexaenoic acid in a time- and concentration-dependent manner. This cytotoxic effect of docosahexaenoic acid is reversed by pretreatment with vitamin E, suggesting that the enhanced toxicity ofGPx-4 knockdown is due to changes in the ability of the cells to handle oxidative stress
Manually annotated by BRENDA team
-
transgenic mouse
Manually annotated by BRENDA team
-
smooth muscle cells
Manually annotated by BRENDA team
subclone s6, SV40 large T antigen-transformed human airway epithelial cells
Manually annotated by BRENDA team
in the blastomeres, Gpx4 granules are formed, and in the blastocysts, even clusters are present mainly around the cell nuclei
Manually annotated by BRENDA team
in the blastomeres, Gpx4 granules are formed, and in the blastocysts, even clusters are present mainly around the cell nuclei
Manually annotated by BRENDA team
-
resting blood platelet
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
PHGPx expression levels are downregulated in poorly differentiated (grade 3) breast invasive ductal carcinoma. PHGPx expression levels decrease gradually with tumor grade from grade 1 to grade 3. Downregulation of PHGPx in cases that showed p53 accumulation compared with cases without p53 immunostaining is observed. PHGPx is downregulated in cases without progesterone receptors immunostaining compared with cases with PR immunostaining
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level
Manually annotated by BRENDA team
-
ovular callus, salt-sensitive and adapted salt-tolerant cell lines
Manually annotated by BRENDA team
extraction of genomic DNA
Manually annotated by BRENDA team
-
keratinized surface epithelium
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level
Manually annotated by BRENDA team
-
basophil leucemia cell line S1 wild-type cell line and (RBL)2H3 cell line overexpressing mitochondrial phospholipid hydroperoxide glutathione peroxidase
Manually annotated by BRENDA team
-
expression level may vary during mammary gland development
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 90% decrease in GPx-4 level
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 60% decrease in GPx-4 level
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 21% decrease in GPx-4 level
Manually annotated by BRENDA team
-
pituicytes
Manually annotated by BRENDA team
in the oocytes, Gpx4 is homogeneously diffused
Manually annotated by BRENDA team
the enzyme is present in the epithelium, stroma, blood vessels, and smooth muscles of oviduct
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 95% decrease in GPx-4 level
Manually annotated by BRENDA team
-
extracellular localisation
Manually annotated by BRENDA team
-
treatment with docosahexaenoic acid results in 85% decrease in GPx-4 level
Manually annotated by BRENDA team
-
PHGPx-overexpressed cell
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
100 nM 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid upregulates phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA and protein expressions. Under persistent oxidative stress the formation of 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid and the 8(S/R)-hydroxy-11(S),12S-trans-epoxyeicosa-5Z,9E,14Z-trienoic acid-induced upregulation of PHGPx constitute a compensatory defense response to protect the vitality and functionality of the cell
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
of arteries
Manually annotated by BRENDA team
-
enzyme is expressed as active peroxidase
Manually annotated by BRENDA team
PHGPx expression is tightly regulated in pachytene spermatocytes, with any spatial-temporal increase in PHGPx expression resulting in damage to spermatogenesis and eventual loss of haploid cells
Manually annotated by BRENDA team
cDNA library
Manually annotated by BRENDA team
additional information