1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase
This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.
Word Map on EC 1.11.1.12
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1.11.1.12
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selenoproteins
-
ferroptosis
-
gsh
-
thioredoxin
-
testis
-
iron-dependent
-
selenite
-
dismutase
-
malondialdehyde
-
catalase
-
selenoenzyme
-
sod
-
hepatokine
-
micronutrient
-
iodothyronine
-
deiodinase
-
selenomethionine
-
se-deficient
-
selenium-containing
-
erastin
-
secis
-
selenium-deficient
-
non-apoptotic
-
ferrostatin-1
-
spermatozoa
-
se-dependent
-
se-adequate
-
apoer2
-
analysis
-
na2seo3
-
midpiece
-
selenocysteine-containing
-
se-containing
-
slc7a11
-
medicine
-
ferroptosis-related
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5'-deiodinase
-
deferoxamine
-
selenocompounds
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15-lipoxygenase
-
ebselen
-
txnrd1
-
hydroperoxy
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gsh-px
-
torula
-
peroxidase-1
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se-enriched
-
biomembranes
-
loohs
-
iron-mediated
-
liver-derived
-
hydroperoxidase
- 1.11.1.12
-
selenoproteins
-
ferroptosis
- gsh
- thioredoxin
- testis
-
iron-dependent
- selenite
- dismutase
- malondialdehyde
- catalase
-
selenoenzyme
- sod
-
hepatokine
-
micronutrient
-
iodothyronine
-
deiodinase
- selenomethionine
-
se-deficient
-
selenium-containing
-
erastin
-
secis
-
selenium-deficient
-
non-apoptotic
-
ferrostatin-1
- spermatozoa
-
se-dependent
-
se-adequate
-
apoer2
- analysis
- na2seo3
-
midpiece
-
selenocysteine-containing
-
se-containing
-
slc7a11
- medicine
-
ferroptosis-related
- 5'-deiodinase
- deferoxamine
-
selenocompounds
- 15-lipoxygenase
- ebselen
- txnrd1
-
hydroperoxy
- gsh-px
- torula
-
peroxidase-1
-
se-enriched
-
biomembranes
-
loohs
-
iron-mediated
-
liver-derived
-
hydroperoxidase
Reaction
2 glutathione
+
Synonyms
AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, TTHERM_00661720, type-4 glutathione peroxidase, VcPHGPx
ECTree
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
Rattus norvegicus Lewis-1AR1
-
-
-
?
2 glutathione + a hydroperoxy-fatty-acyl-[lipid]
glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + a lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
-
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
protection of biomembranes against oxidative damage
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
enzyme reduces amphiphilic peroxides, possibly at the water-lipid interface
-
-
?
glutathione + lipid hydroperoxide
glutathione disulfide + lipid + H2O
-
role in cellular detoxification of a wide variety of lipid hydroperoxides in membranes and internalized lipoproteins
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
in addition to a structural role, PHGPx may also be involved in the non-enzymatic protection of sperm surface against detrimental effects caused by accumulation of modified lipids
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
phospholipid hydroperoxide glutathione peroxidase and 15-lipoxygenase are counterparts in the metabolism of hydroperoxy lipids
-
-
?
additional information
?
-
-
the enzyme appears to be indispensable for structural integrity of spermatozoa and to codetermine sperm motility and viability
-
-
?
additional information
?
-
-
the enzyme plays an essential role in breast cancer cells in alleviating oxidative stress generated from polyunsaturated fatty acid metabolism
-
-
?
additional information
?
-
-
tyrosine phosphorylation of the enzyme may represent an important event in the signaling cascade associated with capacitation that may impact the regulation of hyperactivation of sperm motility and/or mitochondrial function
-
-
?
additional information
?
-
-
PHGPx-/- mice are embryonically lethal at gestation day 7.5. PHGPx+/- mice cells show decreased life span after exposure to irradiation and increased susceptibility to oxidative and genotoxic stress
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
mitochondrial enzyme inhibits the release of cytochrome c from mitochondria by suppressing the peroxidation of cardiolipin in hypoglycaemia-induced apoptosis
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes
-
-
?
additional information
?
-
-
PhGPx prevents NF-kappaB activation, oxLDL-induced proliferation and linoleic acid-induced apoptosis
-
-
?
additional information
?
-
-
the enzyme is not enzymatically active but may be able to interact with modified phospholipids on the membrane, thereby masking or removing potentially damaging lipids from the surface of the parasitpoids eggs
-
-
?
