1.11.1.12: phospholipid-hydroperoxide glutathione peroxidase

This is an abbreviated version!
For detailed information about phospholipid-hydroperoxide glutathione peroxidase, go to the full flat file.

Word Map on EC 1.11.1.12

Reaction

2 glutathione +

a hydroperoxy-fatty-acyl-[lipid]
=
glutathione disulfide
+
a hydroxy-fatty-acyl-[lipid]
+
H2O

Synonyms

AC-PHGPx, Bi-PHGPx, class 4 GPx, CsGPx1, CsGPx2, CsGPx3, CsGPx4, DMPHGPx, glutathione peroxidase 4, glutathione peroxidase-4, glutathione-dependent phospholipid peroxidase, GPX, GPx-4, GPX3, GPx4, GPx41, GPx4A, GPx4B, GPXhs2, GPXle1, hydroperoxide glutathione peroxidase, Hyr1, Hyr1/YIR037W, McPHGPx, More, non-selenocysteine PHGPx, NPGPx, nPHGPx, OsPHGPx, peroxidation-inhibiting protein, peroxidation-inhibiting protein: peroxidase, glutathione (phospholipid hydroperoxide-reducing), PHGPX, phospholipid glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase, phospholipid hydroperoxide glutathione peroxidase A, phospholipid hydroperoxide glutathione peroxidase B, phospholipid hydroperoxide glutathione peroxidase-4, phospholipid-hydroperoxide glutathione peroxidase, phospholipid-hydroperoxide glutathione peroxidases, selenium-dependent glutathione peroxidase type-4, seleno GPx, selenoperoxidase, selenoprotein P, sperm nucleus-specific glutathione peroxidase, type-4 glutathione peroxidase, VcPHGPx

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase

Molecular Weight

Molecular Weight on EC 1.11.1.12 - phospholipid-hydroperoxide glutathione peroxidase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6000
-
below, retina enzyme, gel filtration
16100
-
gel filtration
18000
His6-tagged fusion protein, determined by SDS-PAGE
18300
-
recombinant enzyme, glutathione-S-transferase-tag cut off, SDS-PAGE
18500
-
cytosolic enzyme form, SDS-PAGE
19000
determined by SDS-PAGE
19400
-
determined by gel filtration
21000
21480
calculated from sequence of cDNA
21500
-
mitochondrial enzyme form, SDS-PAGE
22000
-
gel filtration
22500
His6-McPHGPx fusion protein, determined by SDS-PAGE
23000
25900
-
x * 25900, truncated form of nuclear enzyme, lacking the basic nuclear localization signal, SDS-PAGE
34000
-
nucleic enzyme form, SDS-PAGE
66000
-
1 * 66000, SDS-PAGE
69000
-
native PAGE