1.11.1.10: chloride peroxidase

This is an abbreviated version!
For detailed information about chloride peroxidase, go to the full flat file.

Word Map on EC 1.11.1.10

Reaction

RH
+
chloride
+
H2O2
=
RCl
+ 2 H2O

Synonyms

CCPO, Chloride peroxidase, chloroperoxidase, choroperoxidase, CPO, CPO-I, CPO2, heme-thiolate chloroperoxidase, peroxidase, chloride, Vanadium chloride peroxidase, vCPO

ECTree

     1 Oxidoreductases
         1.11 Acting on a peroxide as acceptor
             1.11.1 Peroxidases
                1.11.1.10 chloride peroxidase

Inhibitors

Inhibitors on EC 1.11.1.10 - chloride peroxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-vinyl-2-oxazolidinethione
-
-
azide
diethyl dicarbonate
-
the covalent modification of His105 inhibits the epoxidation and peroxide dismutations catalyzed by CPO
dimethyl dicarbonate
-
the covalent modification of His105 inhibits the epoxidation and peroxide dismutations catalyzed by CPO
hydrogen peroxide
-
the main process leading to peroxide-mediated enzyme inactivation is heme destruction (all tryptophan residues are partially oxidized in the inactive protein). 80000 molar equivalents of hydrogen peroxide are sufficient to reduce the activity of CPO to less than 5%
Sodium cyanoborohydride
-
activity decreases in 38.2 and 92.6% for sodium cyanoborohydride molar excess of 1:1000 and 1:10000
tert-butyl hydroperoxide
-
kinetic studies
thiouracil
-
-
Thiourea
-
competitive with halogen acceptor
additional information
-
not inhibited by sodium cyanoborohydride in molar excess of 1:10 and 1:100
-