1.10.3.4: o-aminophenol oxidase

This is an abbreviated version!
For detailed information about o-aminophenol oxidase, go to the full flat file.

Reaction

4 2-aminophenol + 3 O2 = 2 2-aminophenoxazin-3-one + 6 H2O

Synonyms

2-aminophenol:oxygen oxidoreductase, esophenoxazine synthase, GriF, isophenoxazine synthase, o-aminophenol oxidase, o-aminophenol:O2 oxidoreductase, oxidase, o-aminophenol, phenoxazinone synthase, PHS, PhsA

ECTree

     1 Oxidoreductases

         1.10 Acting on diphenols and related substances as donors

             1.10.3 With oxygen as acceptor

                1.10.3.4 o-aminophenol oxidase

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Results	in table
11	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
1	Expression
4	General Information
1	General Stability
92	Inhibitors
7	Ki Value [mM]
10	KM Value [mM]
9	Metals/Ions
1	Molecular Weight [Da]
27	Natural Substrates/ Products (Substrates)
16	Organism
3	Pathway
10	pH Optimum
2	pH Range
3	Purification (Commentary)
2	Reaction
3	Reaction Type
16	Reference
2	Source Tissue
4	Specific Activity [micromol/min/mg]
4	Storage Stability
47	Substrates and Products (Substrate)
57	Synonyms
1	Systematic Name
10	Temperature Optimum [°C]
2	Temperature Stability [°C]
6	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.10.3.4 - o-aminophenol oxidase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,3-Dimercaptopropanol

Bauhinia monandra

-

-

396432, 713565

2-Aminophenol

Trametes coccinea

-

inhibitory above 0.6 mM

713565

2-Nitrophenol

Streptomyces griseus subsp. griseus

-

-

713565

3-amino-4-hydroxybenzensulfonic acid

2 entries

3-hydroxyanthranilic acid

2 entries

4-hydroxy-3-nitrobenzaldehyde

2 entries

4-hydroxybenzaldehyde

Streptomyces griseus subsp. griseus

-

-

713565

8-hydroxyquinoline

Streptomyces antibioticus

-

-

713565

Ag+

Bauhinia monandra

-

-

396432, 713565

alpha,alpha'-dipyridyl

Streptomyces antibioticus

-

-

713565

aniline

2 entries

anthranilic acid

2 entries

ascorbic acid

2 entries

Atebrin

4 entries

azide

2 entries

Co2+

2 entries

Cu2+

2 entries

CuSO4

Trametes coccinea

-

-

396431, 713565

cyanide

4 entries

cysteine

2 entries

DMSO

Streptomyces antibioticus

Q53692

the native enzyme shows less than 5% residual activity in the presence of DMSO

742261

EDTA

Streptomyces antibioticus

-

-

713565

ethanol

Streptomyces antibioticus

Q53692

the native enzyme shows less than 5% residual activity in the presence of ethanol

742261

ethyl acetate

Streptomyces antibioticus

Q53692

the native enzyme shows less than 5% residual activity in the presence of ethyl acetate

742261

Fe2+

2 entries

Fe3+

2 entries

FeSO4

Trametes coccinea

-

-

396431, 713565

glutathione

2 entries

Hg2+

3 entries

K+

Streptomyces antibioticus

-

-

713565

L-tyrosine

2 entries

methanol

Streptomyces antibioticus

Q53692

the native enzyme shows less than 5% residual activity in the presence of methanol

742261

Mg2+

2 entries

N-ethylmaleimide

3 entries

Na3AsO3

Trametes coccinea

-

-

396431, 713565

NaBH4

Trametes coccinea

-

-

396431, 713565

NH4+

Streptomyces antibioticus

-

-

713565

o-aminophenol

Trametes coccinea

-

substrate inhibition above 0.6 mM

396431

o-Nitrophenol

Streptomyces griseus

-

-

674768

p-chloromercuribenzoate

2 entries

p-Hydroxybenzaldehyde

Streptomyces griseus

-

-

674768

p-hydroxymercuribenzoate

2 entries

phenol

2 entries

Sodium diethyldithiocarbamate

Streptomyces antibioticus

-

-

713565

Zn2+

Streptomyces antibioticus

-

-

713565

3-amino-4-hydroxybenzensulfonic acid

Streptomyces griseus

-

-

674768

3-amino-4-hydroxybenzensulfonic acid

Streptomyces griseus subsp. griseus

-

-

713565

3-hydroxyanthranilic acid

Bauhinia monandra

-

competitive

396432

3-hydroxyanthranilic acid

Bauhinia monandra

-

-

713565

4-hydroxy-3-nitrobenzaldehyde

Streptomyces griseus

-

-

674768

4-hydroxy-3-nitrobenzaldehyde

Streptomyces griseus subsp. griseus

-

-

713565

aniline

Streptomyces griseus

-

-

674768

aniline

Streptomyces griseus subsp. griseus

-

-

713565

anthranilic acid

Bauhinia monandra

-

competitive

396432

anthranilic acid

Bauhinia monandra

-

-

713565

ascorbic acid

Bauhinia monandra

-

-

396432, 713565

ascorbic acid

Trametes coccinea

-

-

396431, 713565

Atebrin

Bauhinia monandra

-

slightly inhibitory

396432

Atebrin

Bauhinia monandra

-

-

713565

Atebrin

Tecoma stans

-

95% inhibition at 0.5 mM, inhibition reversed by FAD

396430

Atebrin

Tecoma stans

-

-

713565

azide

Bauhinia monandra

-

-

396432, 713565

azide

Streptomyces antibioticus

-

-

713565

Co2+

Tecoma stans

-

60% inhibition at 1 mM

396430

Co2+

Tecoma stans

-

-

713565

Cu2+

Bauhinia monandra

-

-

396432, 713565

Cu2+

Streptomyces antibioticus

-

-

713565

cyanide

Bauhinia monandra

-

-

396432, 713565

cyanide

Streptomyces antibioticus

-

-

713565

cyanide

Tecoma stans

-

40% inhibition at 1 mM

396430

cyanide

Tecoma stans

-

-

713565

cysteine

Bauhinia monandra

-

-

396432, 713565

cysteine

Trametes coccinea

-

-

396431, 713565

Fe2+

Bauhinia monandra

-

-

396432, 713565

Fe2+

Streptomyces antibioticus

-

-

713565

Fe3+

Tecoma stans

-

70% inhibition at 1 mM

396430

Fe3+

Tecoma stans

-

-

713565

glutathione

Bauhinia monandra

-

-

396432, 713565

glutathione

Trametes coccinea

-

-

396431, 713565

Hg2+

Bauhinia monandra

-

-

396432, 713565

Hg2+

Tecoma stans

-

56% inhibition at 0.5 mM

396430

Hg2+

Tecoma stans

-

-

713565

L-tyrosine

Streptomyces griseus

-

-

674768

L-tyrosine

Streptomyces griseus subsp. griseus

-

-

713565

Mg2+

Tecoma stans

-

60% inhibition at 1 mM

396430

Mg2+

Tecoma stans

-

-

713565

N-ethylmaleimide

Bauhinia monandra

-

no effect

396432

N-ethylmaleimide

Bauhinia monandra

-

-

713565

N-ethylmaleimide

Trametes coccinea

-

-

396431, 713565

p-chloromercuribenzoate

Tecoma stans

-

60% inhibition at 0.5 mM, inhibition reversed by glutathione

396430

p-chloromercuribenzoate

Trametes coccinea

-

-

396431, 713565

p-hydroxymercuribenzoate

Bauhinia monandra

-

reversed by glutathione or cysteine

396432

p-hydroxymercuribenzoate

Bauhinia monandra

-

-

713565

phenol

Streptomyces griseus

-

-

674768

phenol

Streptomyces griseus subsp. griseus

-

-

713565