1.10.3.3: L-ascorbate oxidase
This is an abbreviated version!
For detailed information about L-ascorbate oxidase, go to the full flat file.
Word Map on EC 1.10.3.3
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1.10.3.3
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copper
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dehydroascorbic
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electrode
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laccase
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oxidases
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ceruloplasmin
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zucchini
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cucurbita
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cucumber
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amperometric
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trinuclear
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apoplastic
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monodehydroascorbate
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squash
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multi-copper
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ascorbate-dependent
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copper-containing
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plastocyanin
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pumpkin
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azurins
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ascorbyl
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ascorbate-glutathione
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myrothecium
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vernicifera
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ferroxidase
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agriculture
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medicine
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analysis
- 1.10.3.3
- copper
-
dehydroascorbic
-
electrode
- laccase
- oxidases
- ceruloplasmin
- zucchini
- cucurbita
- cucumber
-
amperometric
-
trinuclear
- apoplastic
- monodehydroascorbate
- squash
-
multi-copper
-
ascorbate-dependent
-
copper-containing
- plastocyanin
- pumpkin
- azurins
-
ascorbyl
-
ascorbate-glutathione
- myrothecium
- vernicifera
- ferroxidase
- agriculture
- medicine
- analysis
Reaction
4 L-ascorbate + = 4 monodehydroascorbate + 2 H2O
Synonyms
AA oxidase, AA-ox, AAO, AAO1, AAO2, AAO3, Aao4, Af_AO1, AO1, AO4, AOase, ASC oxidase, ascorbase, ascorbate dehydrogenase, ascorbate oxidase, ascorbic acid oxidase, ascorbic oxidase, ASOM, L-ascorbate:O2 oxidoreductase, L-ascorbic acid oxidase, oxidase, ascorbate
ECTree
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Reaction
Reaction on EC 1.10.3.3 - L-ascorbate oxidase
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rate determining step in the catalytic mechanism may involve protonation of an intermediate
Cucurbita pepo medullosa
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
intramolecular electron transfer from type I copper to type III copper is probably the rate-limiting step in enzyme catalysis
Cucurbita pepo medullosa
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
multiple displacement mechanism, enzyme exhibits enzymic memory
Cucurbita pepo condensa
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
mechanism: Cu2+ is reduced to Cu+, which is then reoxidized by oxygen
Cucurbita pepo condensa
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
binding mode of phenolic inhibitors and substrate to active site, binding site in a pocket near type I copper center
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
mechanism and rate constants
Cucurbita pepo medullosa
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4 L-ascorbate + O2 = 4 monodehydroascorbate + 2 H2O
the transition from native dimer to the dimeric intermediate is characterized by the release of copper ions forming the tri-nuclear copper center located at the interface between domain 2 and 3 of each subunit