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1.10.3.11: ubiquinol oxidase (non-electrogenic)

This is an abbreviated version!
For detailed information about ubiquinol oxidase (non-electrogenic), go to the full flat file.

Word Map on EC 1.10.3.11

Reaction

2 ubiquinol +

O2
= 2 ubiquinone + 2 H2O

Synonyms

alternative oxidase, alternative oxidase 1a, alternative oxidase 1b, alternative oxidases, AOX, AOX1, AOX1a, AOX1b, AOX1C, AOX1D, AOX2, AOX2b, AOX2b1, AOX3, AppBC, AtAOX1A, CIO, CioAB, Cox2, CrAOX1, CrAOX2, cyanide-insensitive alternative oxidase, cyanide-insensitive oxidase, cyanide-insensitive quinol oxidase, cyanide-insensitive terminal quinol oxidase, cyanide-resistant alternative oxidase, cyanide-resistant bd-type ubiquinol oxidase, cyanide-resistant oxidase, cyanide-resistant ubiquinol oxidase, CydA, CydB, cytochrome ba3 oxidase, cytochrome bb3 oxidase, cytochrome bd-II, cytochrome bd-type quinol oxidase, cytochrome bo3, cytochrome bo3 ubiquinol oxidase, heme-copper terminal oxidase, mitochondrial alternative oxidase, MpAOX, plant alternative oxidase, TAO, TAOX, trypanosomal alternative oxidase, ubiquinol:oxygen oxidoreductase

ECTree

     1 Oxidoreductases
         1.10 Acting on diphenols and related substances as donors
             1.10.3 With oxygen as acceptor
                1.10.3.11 ubiquinol oxidase (non-electrogenic)

Expression

Expression on EC 1.10.3.11 - ubiquinol oxidase (non-electrogenic)

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
0.2 and 0.3 mM As(V) treatments enhance AOX1a expressions by 2.5- and 5.2folds as compared to control, respectively
0.2 or 0.3 mM As(V) treatment enhances AOX2 expression by 2- and 3.4fold as compared to control
0.3 mM As(V) treatment enhances AOX1d expression tenfold
AOX1b is induced by all As(V) treatments (0.1, 0.2 and 0.3 mM)
auxin is a strong negative regulator of AtAOX1 a transcript abundance
cyclin-dependent kinase E1 (CDKE1), a subunit of the mediator complex, is required for induction of AOX1a in Arabidopsis,acting at both a transcriptional and post-transcriptional level
cytochrome bd-I-deficient Escherichia coli strain cydB has elevated levels of the AppBC cytochrome bd-II terminal oxidase
drought increases the amount of leaf AOX protein
-
PpAOX transcription is induced upon salt stress
rapidly induced when etiolated wheat plants are exposed to a physiologically relevant light level
-
the enzyme is induced both by exogenous cysteine and methionine as well as KCN and antimycin A
-
the enzyme is suppressed by salicylhydroxamic acid at 200 and 400 mM NaCl, in negative correlation with malondialdehyde content
-
the expression of alternative oxidase genes is significantly induced by salt stress (200-400 mM NaCl)
-
the inoculation of Tobacco mosaic virus significantly increases the enzyme transcript and protein levels
the transcription factor MYB29 acts as a negative regulator, not directly by binding the AtAOX1a promoter, but rather by crosstalk with a number of hormone signalling pathways that interact with ETHYLENE RESPONSE FACTOR and WRKY transcription factors
the transcription of AtAOX1a is under strong negative regulation and can be derepressed by activation of the NAC17 transcription factor present in the ER. A variety of ER-bound NAC transcription factors, including NAC13, act downstream of NAC17 to positively regulate AtAOX1a expression. NAC17 is a tail-anchored protein in the ER that must be released by proteolytic cleavage to turn on the expression of AtAOX1a itself and other downstream regulators of AtAOX1a. The transcript abundance of NAC17 is low and not affected by a wide variety of stresses that induce AtAOX1a, and other membrane-bound NAC transcription factors cannot compensate for it. It appears that this positive masterregulator of AOX1a is constitutively expressed at a low level in a latent form and is activated (by proteolytic cleavage on the ER) by mitochondrial dysfunction to turn on AtAOX1a. AtAOX1a is under both negative and positive regulation by WRKY transcription factors that bind to the AtAOX1a promoter
two transcription factors, AOD2 and AOD5, are required for the expression of AOX when the cytochrome pathway is inhibited
-
when Arabidopsis seedlings are illuminated with red or blue light, AOX1a expression can double. The MRR region (a 93-bp portion) in the promoter of AOX1a in Arabidopsis is essential for gene induction by antimycin A and monofluoroacetate, mETC and TCA cycle inhibitors
WRKY transcription factors 15 and 40 act as negative regulators of AtAOX1a. It is possible that they and other negative regulators are displaced when the latent NAC17 transcription factor is released from the ER upon proteolysis, with subsequent competition for the binding site