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1.1.99.39: D-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about D-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.99.39

Reaction

(R)-2-hydroxyglutarate
+
acceptor
=
2-oxoglutarate
+
reduced acceptor

Synonyms

2-hydroxyglutarate dehydrogenase, AtD-2HGDH, D-2-HG dehydrogenase, D-2-HGA, D-2-hydroxyglutarate dehydrogenase, D2-hydroxyglutarate dehydrogenase, D2HDH, D2HGDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.39 D-2-hydroxyglutarate dehydrogenase

Systematic Name

Systematic Name on EC 1.1.99.39 - D-2-hydroxyglutarate dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
(R)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Contains FAD. The enzyme has no activity with NAD+ or NADP+, and was assayed in vitro using artificial electron acceptors. It has lower activity with (R)-lactate, (R)-2-hydroxybutyrate and meso-tartrate, and no activity with the (S) isomers. The mammalian enzyme is stimulated by Zn2+, Co2+ and Mn2+.