1.1.99.37: methanol dehydrogenase (nicotinoprotein)

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For detailed information about methanol dehydrogenase (nicotinoprotein), go to the full flat file.

Word Map on EC 1.1.99.37

1.1.99.37

thermotolerant

formaldehyde

methanolicus

rump

methanol-limited

decameric

Reaction

Synonyms

MDH, MDO, methanol:N,N-dimethyl-4-nitrosoaniline oxidoreductase, NAD-dependent methanol dehydrogenase, NDMA-dependent methanol dehydrogenase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.99 With unknown physiological acceptors

1.1.99.37 methanol dehydrogenase (nicotinoprotein)

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Results	in table
1	Activating Compound
119	AA Sequence
3	Cloned(Commentary)
6	Cofactor
2	Crystallization (Commentary)
3	Expression
3	General Information
4	Inhibitors
1	KM Value [mM]
2	Localization
7	Metals/Ions
5	Molecular Weight [Da]
9	Organism
1	Pathway
1	pI Value
8	Protein Variants
2	Purification (Commentary)
4	Reaction
7	Reference
4	Specific Activity [micromol/min/mg]
2	Storage Stability
11	Substrates and Products (Substrate)
6	Subunits
11	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.1.99.37 - methanol dehydrogenase (nicotinoprotein)

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methanol:acceptor oxidoreductase

Contains Zn2+ and Mg2+. Nicotinoprotein methanol dehydrogenases have a tightly bound NADP+/NADPH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme has been detected in several Gram-positive methylotrophic bacteria, including Amycolatopsis methanolica, Rhodococcus rhodochrous and Rhodococcus erythropolis [1-3]. These enzymes are decameric, and possess a 5-fold symmetry [4]. Some of the enzymes can also dismutate formaldehyde to methanol and formate [5].