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1.1.99.36: alcohol dehydrogenase (nicotinoprotein)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (nicotinoprotein), go to the full flat file.

Word Map on EC 1.1.99.36

Reaction

ethanol
+
acceptor
=
acetaldehyde
+
reduced acceptor

Synonyms

4-nitroso-N, N-dimethylaniline-dependent alcohol dehydrogenase, NDMA-ADH, NDMA-dependent alcohol dehydrogenase, np-ADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.36 alcohol dehydrogenase (nicotinoprotein)

Systematic Name

Systematic Name on EC 1.1.99.36 - alcohol dehydrogenase (nicotinoprotein)

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SYSTEMATIC NAME
IUBMB Comments
ethanol:acceptor oxidoreductase
Contains Zn2+. Nicotinoprotein alcohol dehydrogenases are unique medium-chain dehydrogenases/reductases (MDR) alcohol dehydrogenases that have a tightly bound NAD+/NADH cofactor that does not dissociate during the catalytic process. Instead, the cofactor is regenerated by a second substrate or electron carrier. While the in vivo electron acceptor is not known, N,N-dimethyl-4-nitrosoaniline (NDMA), which is reduced to 4-(hydroxylamino)-N,N-dimethylaniline, can serve this function in vitro. The enzyme from the Gram-positive bacterium Amycolatopsis methanolica can accept many primary alcohols as substrates, including benzylalcohol [1].