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1.1.99.36: alcohol dehydrogenase (nicotinoprotein)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (nicotinoprotein), go to the full flat file.

Word Map on EC 1.1.99.36

Reaction

ethanol
+
acceptor
=
acetaldehyde
 +
reduced acceptor

Synonyms

4-nitroso-N, N-dimethylaniline-dependent alcohol dehydrogenase, NDMA-ADH, NDMA-dependent alcohol dehydrogenase, np-ADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.36 alcohol dehydrogenase (nicotinoprotein)

Inhibitors

Inhibitors on EC 1.1.99.36 - alcohol dehydrogenase (nicotinoprotein)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-butanol
substrate inhibition
1-propanol
substrate inhibition
2-butanol
substrate inhibition
2-propanol
substrate inhibition
acetaldehyde
1 mM, 40% inhibition; 40% inhibition at 1 mM, 60% at 2 mM, and 95% at 10 mM
ADP
10% inhibition at 1 mM, 50% at 10 mM
AMP
10% inhibition at 1 mM, 50% at 10 mM
ATP
10% inhibition at 1 mM, 50% at 10 mM
Cu2+
1 mM, 90% inhibition; 90% inhibition at 1 mM
ethanol
substrate inhibition
Fe2+
1 mM, 90% inhibition; 90% inhibition at 1 mM
Hg2+
100% inhibition at 1 mM
Isobutyramide
competitive to N,N-dimethyl-4-nitrosoaniline
KCN
2 mM, 90% inhibition; 90% inhibition at 2 mM
NaN3
25% inhibition at 2 mM; 2 mM, 25% inhibition
Ni2+
15% inhibition at 1 mM
trans-4-(N,N-dimethylamino)-cinnamaldehyde
inhibition through direct binding to the catalytic zinc ion in a substrate-like geometry. This binding is accompanied by a characteristic red shift of the aldehyde absorbance from 398 nm to 467 nm
trifluoroethanol
nonreactive substrate analogue, competitive to ethanol
Zn2+
1 mM, 40% inhibition; 40% inhibition at 1 mM
additional information
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