1.1.99.30: 2-oxo-acid reductase

This is an abbreviated version!
For detailed information about 2-oxo-acid reductase, go to the full flat file.

Reaction

a (2R)-hydroxy-carboxylate
+
acceptor
=
a 2-oxo-carboxylate
+
reduced acceptor

Synonyms

(2R)-hydroxycarboxlate viologen oxidoreductase, (2R)-hydroxycarboxlate-viologen-oxidoreductase, (2R)-hydroxycarboxylate-viologen-oxidoreductase, 2-oxoacid reductase, D-2-hydroxy acid dehydrogenase, dehydrogenase, D-2-hydroxy acid, HVOR, hydroxy carboxylate viologen oxidoreductase, hydroxycarboxlate-oxidoreductase, hydroxycarboxlate-viologen-oxidoreductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.30 2-oxo-acid reductase

Systematic Name

Systematic Name on EC 1.1.99.30 - 2-oxo-acid reductase

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SYSTEMATIC NAME
IUBMB Comments
(2R)-hydroxy-carboxylate:acceptor oxidoreductase
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.