1.1.99.24: hydroxyacid-oxoacid transhydrogenase
This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.
Word Map on EC 1.1.99.24
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1.1.99.24
-
gamma-hydroxybutyrate
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semialdehyde
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2-hydroxyglutarate
-
iron-containing
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acidurias
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oncometabolite
-
2-ketoglutarate
-
diagnostics
- 1.1.99.24
- gamma-hydroxybutyrate
- semialdehyde
- 2-hydroxyglutarate
-
iron-containing
-
acidurias
-
oncometabolite
- 2-ketoglutarate
- diagnostics
Reaction
Synonyms
ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid
ECTree
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Reference on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kaufman, E.E.; Nelson, T.
An overview of gamma-hydroxybutyrate catabolism: the role of the cytosolic NADP+-dependent oxidoreductase EC 1.1.1.19 and of a mitochondrial hydroxyacid-oxoacid transhydrogenase in the initial, rate-limiting step in this pathway
Neurochem. Res.
16
965-974
1991
Rattus norvegicus
Kaufman, E.E.; Nelson, T.; Fales, H.M.; Levin, D.M.
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria
J. Biol. Chem.
263
16872-16879
1988
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Kardon, T.; Noel, G.; Vertommen, D.; Van Schaftingen, E.
Identification of the gene encoding hydroxyacid-oxoacid transhydrogenase, an enzyme that metabolizes 4-hydroxybutyrate
FEBS Lett.
580
2347-2350
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Struys, E.A.; Verhoeven, N.M.; Ten Brink, H.J.; Wickenhagen, W.V.; Gibson, K.M.; Jakobs, C.
Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias
J. Inherit. Metab. Dis.
28
921-930
2005
Homo sapiens
Lyon, R.C.; Johnston, S.M.; Panopoulos, A.; Alzeer, S.; McGarvie, G.; Ellis, E.M.
Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1
Chem. Biol. Interact.
178
283-287
2009
Homo sapiens (Q8IWW8), Homo sapiens
Gaona-Lopez, C.; Julian-Sanchez, A.; Riveros-Rosas, H.
Diversity and evolutionary analysis of iron-containing (type-III) alcohol dehydrogenases in eukaryotes
PLoS ONE
11
e0166851
2016
Dictyostelium discoideum, Heterostelium pallidum, Capsaspora owczarzaki, Acytostelium subglobosum, Aphanomyces invadans (A0A024TMA3), Saprolegnia parasitica (A0A067BRK4), Thecamonas trahens (A0A0L0DHP5), Phaeodactylum tricornutum (B7FWP2), Dictyostelium purpureum (F1A5G4), Tieghemostelium lacteum (F4PTP3), Thalassiosira oceanica (K0T042), Acanthamoeba castellanii (L8HAM2), Saprolegnia diclina (T0Q1Z2), Aphanomyces astaci (W4G0G7), Reticulomyxa filosa (X6NPJ7), Acytostelium subglobosum LB1, Phaeodactylum tricornutum CCAP 1055/1 (B7FWP2), Aphanomyces astaci APO3 (W4G0G7), Saprolegnia parasitica CBS223.65 (A0A067BRK4), Aphanomyces invadans NJM9701 (A0A024TMA3), Capsaspora owczarzaki ATCC 30864, Saprolegnia diclina VS20 (T0Q1Z2), Thecamonas trahens ATCC 50062 (A0A0L0DHP5), Acanthamoeba castellanii NEFF (L8HAM2)
Yang, X.; Xie, W.; Li, R.M.; Zhou, X.M.; Wang, S.L.; Wu, Q.J.; Yang, N.N.; Xia, J.X.; Yang, Z.Z.; Guo, L.T.; Liu, Y.T.; Zhang, Y.J.
RNA interference-mediated knockdown of the hydroxyacid-oxoacid transhydrogenase gene decreases thiamethoxam resistance in adults of the whitefly Bemisia tabaci
Sci. Rep.
7
41201
2017
Bemisia tabaci (S5YSM1), Bemisia tabaci
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