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1.1.99.24: hydroxyacid-oxoacid transhydrogenase

This is an abbreviated version!
For detailed information about hydroxyacid-oxoacid transhydrogenase, go to the full flat file.

Word Map on EC 1.1.99.24

Reaction

(S)-3-hydroxybutanoate
+
2-oxoglutarate
=
acetoacetate
+
(R)-2-hydroxyglutarate

Synonyms

ADHFE1, alcohol dehydrogenase iron containing 1, HOT, hydroxyacid-oxoacid transhydrogenase, iron-dependent alcohol dehydrogenase ADHFe1, transhydrogenase, hydroxy acid-oxo acid

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.24 hydroxyacid-oxoacid transhydrogenase

KM Value

KM Value on EC 1.1.99.24 - hydroxyacid-oxoacid transhydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.018 - 0.085
2-oxoglutarate
0.06 - 0.3
4-hydroxybutyrate
4.5
D-2-hydroxybutyrate
-
no activity with L-isomer, 30°C, pH 7.1
0.42 - 4.5
D-2-hydroxyglutarate
3
L-3-hydroxybutyrate
-
-
0.0046 - 0.01
Succinic semialdehyde
additional information
additional information
-
no activity with L-isomer of 2-hydroxybutyrate, Km for succinate semialdehyde is below 0.01 mM, 30°C, pH 7.1
-