1.1.99.2: L-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about L-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

Synonyms

2-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase, alpha-hydroxyglutarate dehydrogenase (NAD+ specific), alpha-hydroxyglutarate oxidoreductase, alpha-ketoglutarate reductase, dehydrogenase, 2-hydroxyglutarate, hydroxyglutaric dehydrogenase, L-2-HG dehydrogenase, L-2-HGDH, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutaric acid dehydrogenase, L-2HG dehydrogenase, L-2HGDH, L-alpha-hydroxyglutarate dehydrogenase, L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase, L2HGDH

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.99 With unknown physiological acceptors

                1.1.99.2 L-2-hydroxyglutarate dehydrogenase

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Results	in table
139	AA Sequence
3	Application
1	CAS Registry Number
1	Cloned(Commentary)
11	Cofactor
1	Crystallization (Commentary)
60	Disease/ Diagnostics
3	General Information
1	General Stability
2	Inhibitors
1	Ki Value [mM]
13	KM Value [mM]
5	Localization
1	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
4	pH Range
45	Protein Variants
4	Purification (Commentary)
1	Reaction
5	Reaction Type
16	Reference
16	Source Tissue
3	Specific Activity [micromol/min/mg]
31	Substrates and Products (Substrate)
2	Subunits
22	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 1.1.99.2 - L-2-hydroxyglutarate dehydrogenase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

15

(R)-2-hydroxyglutarate

Alcaligenes sp.

-

-

389902

0.24 - 1.7

(S)-2-hydroxyglutarate

3 entries

0.12

2-oxoglutarate

Alcaligenes sp.

-

-

389902

4 - 13.3

L-2-hydroxyglutarate

2 entries

0.2 - 5.3

NAD+

3 entries

0.14

NADH

Alcaligenes sp.

-

-

389902

additional information

L-2-hydroxyglutarate

2 entries

0.24

(S)-2-hydroxyglutarate

Arabidopsis thaliana

-

at pH 7.4 and 30°C

741137

0.8

(S)-2-hydroxyglutarate

Homo sapiens

-

-

678483

1.7

(S)-2-hydroxyglutarate

Alcaligenes sp.

-

-

389902

4

L-2-hydroxyglutarate

Homo sapiens

-

at pH 8.7 and 37°C

752792

13.3

L-2-hydroxyglutarate

Rattus norvegicus

-

at pH 8.7 and 37°C

752792

0.2

NAD+

Homo sapiens

-

at pH 8.7 and 37°C

752792

0.4

NAD+

Rattus norvegicus

-

at pH 8.7 and 37°C

752792

5.3

NAD+

Alcaligenes sp.

-

-

389902

additional information

L-2-hydroxyglutarate

Homo sapiens

Q9H9P8

107 microM/l, lymphoblast

699377

additional information

L-2-hydroxyglutarate

Homo sapiens

Q9H9P8

112 microM/l, fibroblast

699377