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1.1.99.1: choline dehydrogenase

This is an abbreviated version!
For detailed information about choline dehydrogenase, go to the full flat file.

Word Map on EC 1.1.99.1

Reaction

choline
+
acceptor
=
Betaine aldehyde
+
reduced acceptor

Synonyms

Cdh, CHD, CHDH, ChoDH, choline dehydrogenase, choline oxidase, choline-cytochrome c reductase, choline:(acceptor) oxidoreductase, dehydrogenase, choline, oxidase, choline

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.99 With unknown physiological acceptors
                1.1.99.1 choline dehydrogenase

Systematic Name

Systematic Name on EC 1.1.99.1 - choline dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
choline:acceptor 1-oxidoreductase
A quinoprotein. In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyse the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. In plants, the first reaction is catalysed by EC 1.14.15.7, choline monooxygenase, whereas in animals and many bacteria, it is catalysed by either membrane-bound choline dehydrogenase (EC 1.1.99.1) or soluble choline oxidase (EC 1.1.3.17) [4]. The enzyme involved in the second step, EC 1.2.1.8, betaine-aldehyde dehydrogenase, appears to be the same in plants, animals and bacteria.