1.1.99.1: choline dehydrogenase
This is an abbreviated version!
For detailed information about choline dehydrogenase, go to the full flat file.
Reaction
Synonyms
Cdh, CHD, CHDH, ChoDH, choline dehydrogenase, choline oxidase, choline-cytochrome c reductase, choline:(acceptor) oxidoreductase, dehydrogenase, choline, oxidase, choline
ECTree
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Localization
Localization on EC 1.1.99.1 - choline dehydrogenase
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a nuclear-encoded, membrane-located, mitochondrial enzyme. Human CHD is not an integral membrane protein, but associated to the membrane
a nuclear-encoded, membrane-located, mitochondrial enzyme
CHDH appears to have a mitochondria-targeting sequence at its N-terminus (residues 1 to 38). CHDH is found on both the outer and inner membranes of mitochondria in resting cells. Upon induction of mitophagy, CHDH accumulates on the outer membrane in a mitochondrial potential-dependent manner. CHDH accumulates on the outer membrane following mitochondrial damage. Topology of CHDH in the mitochondrial membrane and mechanism by which CHDH translocates across the mitochondrial membranes, overview
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metabolic organization of betaine synthesis comparable to those of other vertebrates