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1.1.98.7: Ser-type anaerobic sulfatase-maturating enzyme

This is an abbreviated version!
For detailed information about Ser-type anaerobic sulfatase-maturating enzyme, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
a [sulfatase]-L-serine
=
a [sulfatase]-3-oxo-L-alanine
+
5'-deoxyadenosine
+
L-methionine

Synonyms

anaerobic sulfatase-maturating enzyme, anSME, AtsB, cpe0635, nSMEcpe, Ser-type anaerobic sulfatase-maturating enzyme

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.98 With other, known, physiological acceptors
                1.1.98.7 Ser-type anaerobic sulfatase-maturating enzyme

Substrates Products

Substrates Products on EC 1.1.98.7 - Ser-type anaerobic sulfatase-maturating enzyme

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-AVPSSIPSRASILTGM-NH2 + S-adenosyl-L-methionine + dithionite
Ac-AVPS-3-oxo-L-Ala-IPSRASILTGM-NH2 + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
show the reaction diagram
Ac-FENAYTAVPSSIASRASILTGMS-NH2 + S-adenosyl-L-methionine
Ac-FENAYTAVPS-3-oxo-L-Ala-IASRASILTGMS-NH2 + L-methionine + 5'-deoxyadenosine
show the reaction diagram
Ac-YYTSPMSAPARSMLLTGN + S-adenosyl-L-methionine
Ac-YYTSPM-3-oxo-L-Ala-APARSMLLTGN + L-methionine + 5'-deoxyadenosine
show the reaction diagram
a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite
-
-
?
Ac-YYTSPMTAPARSMLLTGN + S-adenosyl-L-methionine
Ac-YYTSPM-(2S)-2-amino-3-oxobutanoyl-APARSMLLTGN + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
show the reaction diagram
a flavodoxin/flavodoxin reductase/NADPH system may substitute for dithionite
-
-
?
acetyl-Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + S-adenosyl-L-methionine
acetyl-Tyr-Tyr-Thr-Ser-Pro-Met-3-oxo-L-Ala-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + L-methionine + 5'-deoxyadenosine
show the reaction diagram
S-adenosyl-L-methionine + a [Klebsiella pneumoniae sulfatase]-L-serine
[Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
show the reaction diagram
the atsB gene product plays a posttranslational role that is essential for the sulfatase to gain its catalytic activity
-
-
?
S-adenosyl-L-methionine + a [sulfatase]-L-serine
a [sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
show the reaction diagram
S-adenosyl-L-methionine + a [sulfatase]-L-serine
[sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
show the reaction diagram
AtsB from Klebsiella pneumoniae can act on sulfatases of other species. The cytosolic cysteine-type sulfatase of Pseudomonas aeruginosa can be converted into a substrate of Klebsiella pneumoniae AtsB if the cysteine is substituted by serine and a signal peptide is added
-
-
?
S-adenosyl-L-methionine + [Klebsiella pneumoniae sulfatase]-L-serine
[Klebsiella pneumoniae sulfatase]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
show the reaction diagram
peptide analysis of the Klebsiella pneumoniae sulfatase protein expressed in the presence of AtsB reveales that half of the polypeptides carry the formylglycine at position 72, while the remaining polypeptides carry the encoded serine. The inactive sulfatase expressed in the absence of AtsB carries exclusively serine 72, demonstrating that the atsB gene is required for formylglycine modification
-
-
?
S-adenosyl-L-methionine + [periplasmic sulfatase AtsA]-L-serine
[periplasmic sulfatase AtsA]-3-oxo-L-alanine + 5'-deoxyadenosine + L-methionine
show the reaction diagram
Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-Ser-Met-Leu-Leu-Thr-Gly-Asn + S-adenosyl-L-methionine + dithionite
Tyr-Tyr-Thr-Ser-Pro-Met-Ser-Ala-Pro-Ala-Arg-3-oxo-L-Ala-Met-Leu-Leu-Thr-Gly-Asn + L-methionine + 5'-deoxyadenosine + sulfur dioxide + H2O
show the reaction diagram
[arylsulfatase]-L-serine + S-adenosyl-L-methionine + reduced acceptor
[arylsulfatase]-3-oxo-L-alanine + L-methionine + 5'-deoxyadenosine + acceptor + H2O
show the reaction diagram
-
-
-
?
additional information
?
-