1.1.98.6: ribonucleoside-triphosphate reductase (formate)

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For detailed information about ribonucleoside-triphosphate reductase (formate), go to the full flat file.

Reaction

Synonyms

anaerobic ribonucleoside-triphosphate reductase, anaerobic ribonucleotide reductase, class III ribonucleoside-triphosphate reductase, nrdD

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.98 With other, known, physiological acceptors

                1.1.98.6 ribonucleoside-triphosphate reductase (formate)

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Results	in table
10	Activating Compound
158	AA Sequence
2	Application
5	Cloned(Commentary)
7	Cofactor
2	Crystallization (Commentary)
4	General Information
7	Inhibitors
2	Ki Value [mM]
6	KM Value [mM]
3	Metals/Ions
5	Molecular Weight [Da]
19	Organism
11	Pathway
21	Protein Variants
2	Purification (Commentary)
1	Reaction
19	Reference
11	Specific Activity [micromol/min/mg]
21	Substrates and Products (Substrate)
5	Subunits
10	Synonyms
1	Systematic Name

Crystallization

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Crystallization on EC 1.1.98.6 - ribonucleoside-triphosphate reductase (formate)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

quantum chemical calculation of reaction mechanism. Carbon dioxide is formed from formate, which is present as a cofactor. The formate first forms a formyl radical. The next step, where the formyl radical protonates the 3'-keto group of the substrate, is rate limiting with a calculated total barrier of 19.9 kcal/mol, in reasonable agreement with the experimental rate-limiting barrier of 17 kcal/mol. Zero-point and entropy effects are quite significant in lowering the barrier

Escherichia coli

-

740895

C-terminal region contains a Zn(Cys)4 center structurally related to the zinc ribbon motif and to rubredoxin and rubrerythrin. Residues Cys543, Cys546, Cys561, and Cys564 coordinate the metal ion tetrahedrally

Tequatrovirus T4

P07071

660352