1.1.5.4: malate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about malate dehydrogenase (quinone), go to the full flat file.

Reaction

Synonyms

EC 1.1.3.3, EC 1.1.99.16, FAD-dependent malate dehydrogenase, L-malate-quinone oxidoreductase, L-malate:quinone oxidoreductase, malate dehydrogenase, malate dehydrogenase (acceptor), malate-quinone oxidoreductase, malate-vitamin K reductase, malate: quinone oxidoreductase, malate:quinine oxidoreductase, malate:quinone oxidoreductase, malate:quinone reductase, menaquinone reductase, Mqo, MqoB, MQR, PfMQO

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.5 With a quinone or similar compound as acceptor

                1.1.5.4 malate dehydrogenase (quinone)

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Results	in table
11	Activating Compound
13438	AA Sequence
3	Application
1	CAS Registry Number
9	Cloned(Commentary)
18	Cofactor
14	General Information
9	IC50 Value
31	Inhibitors
4	kcat/KM [mM/s]
1	Ki Value [mM]
13	KM Value [mM]
15	Localization
1	Metals/Ions
7	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
45	Organism
11	Pathway
8	pH Optimum
2	pH Range
7	pH Stability
1	pI Value
2	Protein Variants
7	Purification (Commentary)
1	Reaction
29	Reference
3	Source Tissue
4	Specific Activity [micromol/min/mg]
5	Storage Stability
63	Substrates and Products (Substrate)
3	Subunits
55	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
4	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 1.1.5.4 - malate dehydrogenase (quinone)

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00115

1,1'-[furan-2,5-diylbis(3-chloro-1,4-phenylene)]bisguanidine

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.001099

2-cycloheptyl-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethylpyrazol-3-one

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.00396

2-[3-chloro-4-[5-[2-chloro-4-(diaminomethylideneamino)phenyl]furan-2-yl]phenyl]guanidine

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.0000726

3-cycloheptyl-4abeta,5,8,8abeta-tetrahydro-1-[3-[4-[4-(2H-tetrazole-5-yl)phenoxy]butoxy]-4-methoxyphenyl]phthalazine-4(3H)-one

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.0036

3-[7-[(3,5-dimethylbenzyl)oxy]-4,8-dimethyl-2-oxo-2H-chromen-3-yl]propanoic acid

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.000343

5-bromo-2-chloro-N-(5-mercapto-1,3,4-thiadiazol-2-yl)benzamide

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

0.00925

ferulenol

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

762760

-

0.00406

N-[2-(1H-indol-3-yl)ethyl]-2-oxo-2H-chromene-3-carboxamide

Plasmodium falciparum

C6KT09

pH 7.0, 37°C

763119

-

additional information

additional information

Mycolicibacterium smegmatis

-

IC50 for polymyxin B is 4.2 microg/ml, IC50 for nanaomycin is 49 microg/ml

698670

-