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1.1.5.13: (S)-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about (S)-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

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(S)-2-hydroxyglutarate
+
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a quinone
=
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2-oxoglutarate
+
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a quinol

Synonyms

L-2-HG dehydrogenase, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutarate oxygenase, L-2HG dehydrogenase, L-2HGDH, L2HG dehydrogenase, L2HG:quinone oxidoreductase, L2HGDH, lhgO, YgaF

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                EC 1.1.5.131.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.5.13 - (S)-2-hydroxyglutarate dehydrogenase

for references in articles please use BRENDA:EC1.1.5.13

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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY hide
Reversibility
r=reversible
ir=irreversible
?=not specified
D-2-hydroxyglutarate + 2,6-dichlorophenolindophenol
2-oxoglutarate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
Substrates: 3.7% activity compared to L-2-hydroxyglutarate
Products: -
?
L-2-hydroxyglutarate + 2,6-dichlorophenolindophenol
2-oxoglutarate + reduced 2,6-dichlorophenolindophenol
show the reaction diagram
-
Substrates: -
Products: -
?
L-2-hydroxyglutarate + a quinone
2-oxoglutarate + a quinol
show the reaction diagram
L-2-hydroxyglutarate + iodonitrotetrazolium
2-oxoglutarate + reduced iodonitrotetrazolium
show the reaction diagram
-
Substrates: -
Products: -
?
L-2-hydroxyglutarate + menaquinone-4
2-oxoglutarate + menaquinol-4
show the reaction diagram
-
Substrates: -
Products: -
?
L-2-hydroxyglutarate + O2
2-oxoglutarate + H2O2
show the reaction diagram
-
Substrates: -
Products: -
?
L-2-hydroxyglutarate + oxidized o-phenylendiamine
alpha-ketoglutarate + reduced o-phenylendiamine
show the reaction diagram
-
Substrates: experimental setup
Products: -
ir
L-2-hydroxyglutarate + ubiquinone-1
2-oxoglutarate + ubiquinol-1
show the reaction diagram
-
Substrates: -
Products: -
?
additional information
?
-