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1.1.5.13: (S)-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about (S)-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

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(S)-2-hydroxyglutarate
+
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a quinone
=
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2-oxoglutarate
+
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a quinol

Synonyms

L-2-HG dehydrogenase, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutarate oxygenase, L-2HG dehydrogenase, L-2HGDH, L2HG dehydrogenase, L2HG:quinone oxidoreductase, L2HGDH, lhgO, YgaF

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                EC 1.1.5.131.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

Reference

Reference on EC 1.1.5.13 - (S)-2-hydroxyglutarate dehydrogenase

for references in articles please use BRENDA:EC1.1.5.13

Please use the Reference Search for a specific query.

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kalliri, E.; Mulrooney, S.B.; Hausinger, R.P.
Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase
J. Bacteriol.
190
3793-3798
2008
Escherichia coli
Manually annotated by BRENDA team
Rzem, R.; Van Schaftingen, E.; Veiga-da-Cunha, M.
The gene mutated in L-2-hydroxyglutaric aciduria encodes L-2-hydroxyglutarate dehydrogenase
Biochimie
88
113-116
2006
Homo sapiens
Manually annotated by BRENDA team
Shelar, S.; Shim, E.H.; Brinkley, G.J.; Kundu, A.; Carobbio, F.; Poston, T.; Tan, J.; Parekh, V.; Benson, D.; Crossman, D.K.; Buckhaults, P.J.; Rakheja, D.; Kirkman, R.; Sato, Y.; Ogawa, S.; Dutta, S.; Velu, S.E.; Emberley, E.; Pan, A.; Chen, J.; Huang, T.; Absher, D.; Becker, A.; Kunick, C.; Sudarshan, S.
Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer
Clin. Cancer Res.
24
6433-6446
2018
Homo sapiens
Manually annotated by BRENDA team
Kalliri, E.; Mulrooney, S.; Hausinger, R.
Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase
J. Bacteriol.
190
3793-3798
2008
Escherichia coli
Manually annotated by BRENDA team
Knorr, S.; Sinn, M.; Galetskiy, D.; Williams, R.; Wang, C.; Mueller, N.; Mayans, O.; Schleheck, D.; Hartig, J.
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate
Nat. Commun.
9
5071
2018
Escherichia coli
Manually annotated by BRENDA team
Huedig, M.; Maier, A.; Scherrers, I.; Seidel, L.; Jansen, E.E.; Mettler-Altmann, T.; Engqvist, M.K.; Maurino, V.G.
Plants possess a cyclic mitochondrial metabolic pathway similar to the mammalian metabolic repair mechanism involving malate dehydrogenase and L-2-hydroxyglutarate dehydrogenase
Plant Cell Physiol.
56
1820-1830
2015
Arabidopsis thaliana
Manually annotated by BRENDA team
Rzem, R.; Veiga-da-Cunha, M.; Noel, G.; Goffette, S.; Nassogne, M.C.; Tabarki, B.; Schoeller, C.; Marquardt, T.; Vikkula, M.; Van Schaftingen, E.
A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria
Proc. Natl. Acad. Sci. USA
101
16849-16854
2004
Homo sapiens
Manually annotated by BRENDA team