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1.1.5.13: (S)-2-hydroxyglutarate dehydrogenase

This is an abbreviated version!
For detailed information about (S)-2-hydroxyglutarate dehydrogenase, go to the full flat file.

Reaction

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(S)-2-hydroxyglutarate
+
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a quinone
=
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2-oxoglutarate
+
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a quinol

Synonyms

L-2-HG dehydrogenase, L-2-hydroxyglutarate dehydrogenase, L-2-hydroxyglutarate oxygenase, L-2HG dehydrogenase, L-2HGDH, L2HG dehydrogenase, L2HG:quinone oxidoreductase, L2HGDH, lhgO, YgaF

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                EC 1.1.5.131.1.5.13 (S)-2-hydroxyglutarate dehydrogenase

Engineering

Engineering on EC 1.1.5.13 - (S)-2-hydroxyglutarate dehydrogenase

for references in articles please use BRENDA:EC1.1.5.13

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DELTA-exon9
E176D
K71E
-
the mutation is associated with L-2-hydroxyglutaric aciduria
K81E
-
the mutation leads to severely reduced enzyme activity and is associated with L-2-hydroxyglutaric aciduria