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1.1.5.12: D-lactate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase (quinone), go to the full flat file.

Reaction

(R)-lactate
+
a quinone
=
pyruvate
+
a quinol

Synonyms

Cg1027, D-iLDH, DLD, Dld2, Fe-S D-iLDH, lldE, NAD-independent D-lactate dehydrogenase, pp4737, quinone-dependent D-lactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.5 With a quinone or similar compound as acceptor
                1.1.5.12 D-lactate dehydrogenase (quinone)

General Information

General Information on EC 1.1.5.12 - D-lactate dehydrogenase (quinone)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the isolated FAD-containing dehydrogenase domain retains 2-hydroxyacid-oxidizing activity, although it decreased compared to the full Fe-S D-iLDH. Compared to the intact enzyme, the FAD-containing dehydrogenase domain shows increased catalytic efficiency with cytochrome c as the electron acceptor, but it completely lost the ability to use coenzyme Q10. The Fe-S oxidoreductase domain functions as an electron transfer component to facilitate the utilization of quinone as an electron acceptor by Fe-S D-iLDH, and it helps the enzyme associate with the cell membrane
physiological function