1.1.3.47: 5-(hydroxymethyl)furfural oxidase
This is an abbreviated version!
For detailed information about 5-(hydroxymethyl)furfural oxidase, go to the full flat file.
Word Map on EC 1.1.3.47
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1.1.3.47
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synthesis
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2,5-furandicarboxylic
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biocatalyst
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bio-based
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biocatalytic
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oxidases
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putida
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methylovorus
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basilensis
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fed-batch
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petroleum-based
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terephthalate
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cupriavidus
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flavin
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ornithinolytica
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biomass-derived
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raoultella
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eugenol
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enantioselective
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polyesters
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cosolvents
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one-pot
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fusing
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biotechnology
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biofuel production
- 1.1.3.47
- synthesis
-
2,5-furandicarboxylic
-
biocatalyst
-
bio-based
-
biocatalytic
- oxidases
- putida
- methylovorus
- basilensis
-
fed-batch
-
petroleum-based
- terephthalate
-
cupriavidus
- flavin
- ornithinolytica
-
biomass-derived
-
raoultella
- eugenol
-
enantioselective
-
polyesters
-
cosolvents
-
one-pot
-
fusing
- biotechnology
- biofuel production
Reaction
Synonyms
5-hydroxymethylfurfural oxidase, AAO, AOX1, GaoB, Glox2, Glox3, GLRG_02805, HFMO, HMF oxidase, HMF/furfural oxidoreductase, HmfH, HMFO, MPQ_0130
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Natural Substrates Products
Natural Substrates Products on EC 1.1.3.47 - 5-(hydroxymethyl)furfural oxidase
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REACTION DIAGRAM
5-(dihydroxymethyl)furan-2-carbaldehyde + O2
5-formylfuran-2-carboxylate + H2O2
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5-(dihydroxymethyl)furan-2-carboxylate + O2
furan-2,5-dicarboxylate + H2O2
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5-(hydroxymethyl)furfural + O2
furan-2,5-dicarbaldehyde + H2O2
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5-formylfuran-2-carboxylate + H2O
5-(dihydroxymethyl)furan-2-carboxylate
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furan-2,5-dicarbaldehyde + H2O
5-(dihydroxymethyl)furan-2-carbaldehyde
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additional information
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the ability of fungal aryl-alcohol oxidase (AAO) to oxidize 5-hydroxymethylfurfural (HMF) results in almost complete conversion into 2,5-formylfurancarboxylic acid (FFCA) in a few hours. The reaction starts with alcohol oxidation, yielding 2,5-diformylfuran (DFF), which is rapidly converted into FFCA by carbonyl oxidation, most probably without leaving the enzyme active site. AAO is combined with an unspecific peroxygenase, UPO, EC 1.11.2.1, from Agrocybe aegerita for full oxidative conversion of 5-hydroxymethylfurfural in an enzymatic cascade. This peroxygenase belongs to the recently described superfamily of hemethiolate peroxidases, and is capable of incorporating peroxide-borne oxygen into diverse substrate molecules. In contrast to AAO, the UPO reaction starts with oxidation of the HMF carbonyl group, yielding 2,5-hydroxymethylfurancarboxylic, which is converted into 2,5-formylfurancarboxylic acid and some 2,5-furandicarboxylic acid
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2,5-diformylfuran + 2 O2
2,5-furandicarboxylic acid + H2O2
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2,5-diformylfuran + 2 O2
2,5-furandicarboxylic acid + H2O2
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furan-2,5-dicarboxylate + 3 H2O2
overall reaction. the enzyme is involved in degradation of 5-(hydroxymethyl)furfural
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5-(hydroxymethyl)furfural + 3 O2 + 2 H2O
furan-2,5-dicarboxylate + 3 H2O2
overall reaction
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5-(hydroxymethyl)furfural + 3 O2 + 2 H2O
furan-2,5-dicarboxylate + 3 H2O2
the enzyme is involved in the degradation and detoxification of 5-(hydroxymethyl)furfural
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