1.1.3.46: 4-hydroxymandelate oxidase
This is an abbreviated version!
For detailed information about 4-hydroxymandelate oxidase, go to the full flat file.
Word Map on EC 1.1.3.46
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1.1.3.46
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oxidases
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fmn-dependent
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amycolatopsis
-
four-electron
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flavin
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coelicolor
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benzoylformate
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two-electron
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mononucleotide
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vancomycin
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nonribosomal
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orientalis
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chloroeremomycin
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synthesis
- 1.1.3.46
- oxidases
-
fmn-dependent
-
amycolatopsis
-
four-electron
- flavin
- coelicolor
- benzoylformate
-
two-electron
- mononucleotide
- vancomycin
-
nonribosomal
- orientalis
- chloroeremomycin
- synthesis
Reaction
Synonyms
4HmO, fegC, HmO, hydroxymandelate oxidase, L-4-hydroxymandelate oxidase, p-hydroxymandelate oxidase, Sco3228
ECTree
1.1.3.46 4-hydroxymandelate oxidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.1.3.46 - 4-hydroxymandelate oxidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-chloro-(S)-mandelate + O2
(2-chlorophenyl)(oxo)acetic acid + H2O2
-
-
-
?
4-bromo-(S)-mandelate + O2
(4-bromophenyl)(oxo)acetic acid + H2O2
-
-
-
?
4-chloro-(S)-mandelate + O2
(4-chlorophenyl)(oxo)acetic acid + H2O2
-
-
-
?
4-trifluoromethyl-(S)-mandelate + O2
(4-trifluoromethylphenyl)(oxo)acetic acid + H2O2
-
-
-
?
additional information
?
-
O2 is the prerequisite electron acceptor in the oxidation reaction. No substrates: (R)-4-hydroxymandelate, (S)-2-methylphenylacetate
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-
-
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate. The enzyme is involed in the biosynthesis of the non-proteinogenic amino acid (S)-4-hydroxyphenylglycine a constituent of peptide antibiotics
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
(S)-2-hydroxy-2-(4-hydroxyphenyl)acetate i.e. (S)-4-hydroxymandelate
2-(4-hydroxyphenyl)-2-oxoacetate i.e. 4-hydroxyphenylglyoxylate
-
?
(S)-3,5-dihydroxymandelate + O2
2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-3,5-dihydroxymandelate + O2
2-(3,5-dihydroxyphenyl)-2-oxoacetate + H2O2
the enzyme is involed in the biosynthesis of (S)-4-hydroxyphenylglycine and (S)-3,5-dihydroxyphenylglycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-4-hydroxymandelate + O2
2-(4-hydroxyphenyl)-2-oxoacetate + H2O2
-
-
-
?
(S)-mandelate + O2
2-phenyl-2-oxoacetate + H2O2
no activity with (R)-mandelate
-
-
?
