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1.1.2.8: alcohol dehydrogenase (cytochrome c)

This is an abbreviated version!
For detailed information about alcohol dehydrogenase (cytochrome c), go to the full flat file.

Word Map on EC 1.1.2.8

Reaction

a primary alcohol
+
2 ferricytochrome c
=
an aldehyde
+ 2 ferrocytochrome c + 2 H+

Synonyms

Ca2+-dependent PQQ-ADH, EC 1.1.99.8, EDH, ethanol dehydrogenase, exaA, exaF, PedE, PedH, PpADH, PP_2674, PP_2679, PQQ-ADH, PQQ-alcohol dehydrogenase, PQQ-dependent alcohol dehydrogenase, PQQ-dependent type I alcohol dehydrogenase, PQQ-DH9, pyrroloquinoline quinone ethanol dehydrogenase, pyrroloquinoline quinone-dependent alcohol dehydrogenases, pyrroloquinoline quinone-dependent dehydrogenase, pyrroloquinoline quinone-dependent quinoprotein alcohol dehydrogenase, pyrroquinoline quinone-dependent alcohol dehydrogenase, quinoprotein alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.2 With a cytochrome as acceptor
                1.1.2.8 alcohol dehydrogenase (cytochrome c)

Activating Compound

Activating Compound on EC 1.1.2.8 - alcohol dehydrogenase (cytochrome c)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Butylamine
-
-
Dimethylamine
-
-
dipropylamine
-
-
ethanol
-
does not affect the adhS gene expression but induces PQQ-ADH activity
ethylamine
-
inhibitory at high concentrations
heptylamine
-
-
Hexylamine
-
-
Isobutylamine
-
slight activation
methylamine
octylamine
-
-
pentylamine
-
the alcohol oxidation activity of PpADH is strongly enhanced by pentylamine and the affinity for substrates is also improved by pentylamine as an activator, inhibitory at high concentrations
Propylamine
-
-
triethylamine
-
-
trimethylamine
-
-
tripropylamine
-
-
additional information
-
the enzyme requires ammonia or primary amines as activators in in vitro assays with artificial electron acceptors, the enzyme is activated by various primary amines, dimethylamine, and trimethylamine. tert-Butylamine is a poor activator. The hydrophobic interaction contributes to the binding of amine activators to the binding site in the enzyme
-