1.1.1.B66: acyclic imino acid reductase

This is an abbreviated version!
For detailed information about acyclic imino acid reductase, go to the full flat file.

Reaction

Synonyms

asymmetric reductase, BSp5, imino acid reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.B66 acyclic imino acid reductase

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Results	in table
1	AA Sequence
1	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
3	General Information
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	pH Optimum
6	Protein Variants
1	Purification (Commentary)
2	Reaction
1	Reference
4	Substrates and Products (Substrate)
2	Subunits
3	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 1.1.1.B66 - acyclic imino acid reductase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(4E)-5-carbamimidamido-2-iminopent-4-enoic acid + NADPH + H+

D-2-dehydroarginine + NADP+

Bacillus sp. 5mfcol3.1

A0A1I4FUG4

-

763186

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?

5-carbamimidamido-2-iminopentanoic acid + NADPH + H+

D-arginine + NADP+

Bacillus sp. 5mfcol3.1

A0A1I4FUG4

Bsp5 shows poor activity in the reverse reaction direction

763186

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-

?

additional information

?

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2 entries

additional information

?

-

Bacillus sp. 5mfcol3.1

A0A1I4FUG4

enzyme Bsp5 reduces acyclic imino acids produced in situ by a partner oxidase

763186

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-

additional information

?

-

Bacillus sp. 5mfcol3.1

A0A1I4FUG4

the asymmetric reductase intercepts acyclic imino acids produced in situ by a partner oxidase (Ind4 from Paenibacillus sp.) in a coupled assay, overview. Nonenzymatic hydrolysis of acyclic imino acids gives compounds (4E)-5-carbamimidamido-2-oxopent-4-enoic acid and 5-carbamimidamido-2-oxopentanoic acid. Bsp5 fails to reduce 5-carbamimidamido-2-oxopentanoic acid, and incubation of Bsp5 with 2-methylpyrroline also results in no reaction. Bsp5 lacks imine reducing activity on cyclic substrates. LC-MS analysis of the molecules

763186

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