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1.1.1.B60: D-sorbitol dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about D-sorbitol dehydrogenase (NADP+), go to the full flat file.

Reaction

D-sorbitol
+
NADP+
=
L-sorbose
+
NADPH
+
H+

Synonyms

D-sorbitol dehydrogenase (NADP+), D-sorbitol:NADP+ oxidoreductase (L-sorbose-forming), GoSLDH, SLDH, sorbitol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B60 D-sorbitol dehydrogenase (NADP+)

Inhibitors

Inhibitors on EC 1.1.1.B60 - D-sorbitol dehydrogenase (NADP+)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
D-sorbitol
-
inhibitory at more than 10% (w/v)
NADPH
-
product inhibition. Escherichia coli(gosldh-lrenox) producing both GoSLDH for D-sorbitol oxidation and LreNOX (NAD(P)H oxidase from Lactobacillus reuteri) for NADP+ regeneration is generated and used for L-sorbose production. L-Sorbose production by Escherichi coli(gosldh-lrenox) reaches 4.1 g/l after 40 min, which was 20.5fold higher than that of Escherichia coli(gosldh). This system reduces the NADPH inhibition effect in the GoSLDH reaction and enables high production of L-sorbose from D-sorbitol