1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)

This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.

Word Map on EC 1.1.1.B4

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, SADH, SDR, secondary alcohol dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase (NADH)

Turnover Number

Turnover Number on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1 - 1.7
(R)-2-butanol
1.1 - 1.9
(R)-2-pentanol
2.31 - 6.9
1-(2-pyridyl)acetone
-
1.5 - 1.7
1-(2-thienyl)acetone
-
0.47
1-(3-pyridyl)acetone
-
pH 6.5, 50C, mutant I86A
-
14.9
1-(3-thienyl)acetone
-
pH 6.5, 50C, mutant I86A
-
1.7 - 13.1
1-(4-pyridyl)acetone
-
6.5 - 23.3
1-phenylpropanone
2.2 - 2.9
2',4'-difluoro-acetophenone
-
0.18
2'-methylacetophenone
-
pH 6.5, 50C, wild-type enzyme
-
25.5
2,2,2-trifluoroacetophenone
-
pH 6.0, 65C, recombinant enzyme, reduction reaction
36.1
2,3-Butanedione
-
pH 7.4, 30C
6.5
3'-bromo-acetophenone
-
pH 6.5, 50C, wild-type enzyme
0.66 - 12.3
3'-chloro-acetophenone
0.61
3'-iodo-acetophenone
-
pH 6.5, 50C, wild-type enzyme
-
0.08
3'-methoxy-acetophenone
-
pH 6.5, 50C, wild-type enzyme
2
3'-methylacetophenone
-
pH 6.5, 50C, wild-type enzyme
0.04
3'-trifluoro-acetophenone
-
pH 6.5, 50C, wild-type enzyme
-
21.1 - 114
3,5-bis(trifluoromethyl)acetophenone
1.01 - 35
acetone
8.2 - 15.8
acetophenone
3.97
ethyl 2-oxopropanoate
pH 6.5, 50C
5.2
ethyl 4-chloro-3-oxobutanoate
-
pH 7.4, 30C
50.1
ethylbenzoylformate
-
pH 6.0, 65C, recombinant enzyme, reduction reaction
0.84
NAD+
-
pH 6.0, 65C, recombinant enzyme, reduction reaction
23.6 - 100
NADH