1.1.1.B4: (R)-specific secondary alcohol dehydrogenase (NADH)

This is an abbreviated version!
For detailed information about (R)-specific secondary alcohol dehydrogenase (NADH), go to the full flat file.

Word Map on EC 1.1.1.B4

Reaction

(R)-R-CHOH-R'
+
NAD+
=
R-CO-R'
+
NADH
+
H+

Synonyms

(R)-epinephrine dehydrogenase, ADH, ADH1, ADH2, ADHTt, carbonyl reductase, carbonyl reductase (NADH, specific for (S)-configuration of alcohol), CHY1186, CpCR, mLDH, More, SADH, SDR, secondary alcohol dehydrogenase, short-chain NAD(H)-dependent alcohol dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.B4 (R)-specific secondary alcohol dehydrogenase (NADH)

KCat KM Value

KCat KM Value on EC 1.1.1.B4 - (R)-specific secondary alcohol dehydrogenase (NADH)

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.26 - 1.6
1-(2-pyridyl)acetone
-
0.26 - 0.51
1-(2-thienyl)acetone
-
0.2 - 0.63
1-(3-pyridyl)acetone
-
4.3
1-(3-thienyl)acetone
-
pH 6.5, 50C, mutant I86A
-
1.05 - 2.4
1-(4-pyridyl)acetone
-
1.5 - 8.1
1-phenylpropanone
0.23 - 0.62
2',4'-difluoro-acetophenone
-
0.018
2'-methylacetophenone
-
pH 6.5, 50C, wild-type enzyme
-
50.1
2,3-Butanedione
-
pH 7.4, 30C
0.65
3'-bromo-acetophenone
-
pH 6.5, 50C, wild-type enzyme
0.41 - 1.3
3'-chloro-acetophenone
0.16
3'-iodo-acetophenone
-
pH 6.5, 50C, wild-type enzyme
-
0.21
3'-methoxy-acetophenone
-
pH 6.5, 50C, wild-type enzyme
0.18
3'-methylacetophenone
-
pH 6.5, 50C, wild-type enzyme
0.025
3'-trifluoro-acetophenone
-
pH 6.5, 50C, wild-type enzyme
-
36.8 - 463
3,5-bis(trifluoromethyl)acetophenone
1.08 - 1.33
acetone
1.9 - 14.9
acetophenone
4.1
ethyl 4-chloro-3-oxobutanoate
-
pH 7.4, 30C
75 - 4207
NADH
5100 - 9300
NADPH