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1.1.1.94: glycerol-3-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.94

Reaction

sn-glycerol 3-phosphate
+
NAD(P)+
=
glycerone phosphate
+
NAD(P)H
+
H+

Synonyms

CvGPD1, G3PD, G3PDH, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase (NADP), glycerol phosphate dehydrogenase (nicotinamide adenine dinucleotide (phosphate)), GPDH, GpsA, L-glycerol-3-phosphate:NAD(P) oxidoreductase, NAD(P)H-dependent dihydroxyacetone-phosphate reductase, NAD(P)H-dependent glycerol-3-phosphate dehydrogenase, NADP-dependent glycerol-3-phosphate dehydrogenase, RP442, sn-glycerol-3-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.94 glycerol-3-phosphate dehydrogenase [NAD(P)+]

Application

Application on EC 1.1.1.94 - glycerol-3-phosphate dehydrogenase [NAD(P)+]

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
agriculture
-
in transgenic Arabidopsis thaliana lines with a feedback-resistant glycerol-3-phosphate dehydrogenase gene from Escherichia coli, feedback-resistant glycerol-3-phosphate dehydrogenase is detected in the cytosol, but augmented glycerol-3-phosphate levels are observed in the cytosol as well as in chloroplasts. Glycerolipid composition and fatty acid positional distribution analyses reveal an altered fatty acid flux that affects not only the molar ratios of glycerolipid species but also their fatty acid composition. Changes in glycerol-3-phosphate metabolism cause altered expression of a broad array of genes. Transcript levels of the enzymes involved in the prokaryotic pathway are mostly induced, whereas genes of the eukaryotic pathway enzymes are largely suppressed
synthesis
development of a whole-cell biocatalyst for NAD(P)H cofactor regeneration that employs permeabilized Escherichia coli cells in which the glpD and gldA genes are deleted and the gpsA gene is overexpressed. The biocatalyst involves an economical substrate, bifunctional regeneration of NAD(P)H, and simple reaction conditions as well as a stable environment for enzymes, and is applicable to a variety of oxidoreductase reactions requiring NAD(P)H regeneration