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BRENDA support

1.1.1.85: 3-isopropylmalate dehydrogenase

This is an abbreviated version!
For detailed information about 3-isopropylmalate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.85

Reaction

(2R,3S)-3-isopropylmalate
+
NAD+
=
(2S)-2-isopropyl-3-oxosuccinate
+
NADH
+
H+

Synonyms

2-hydroxy-4-methyl-3-carboxyvalerate:NAD+ oxidoreductase, 2R,3S-isopropylmalate:NAD+ oxidoreductase (decaboxylating), 3-IPM dehydrogenase, 3-IPM-DH, 3-isopropylmalate dehydrogenase, 3-isopropylmalateDH, APS IPMDH, beta-IPM dehydrogenase, beta-IPMDH, beta-isopropylmalate dehydrogenase, beta-isopropylmalic enzyme, Bs3-isopropylmalateDH, dehydrogenase, 3-isopropylmalate, IMDH, IPMDH, IPMDH1, IPMDH2, IPMDH3, isopropylmalate dehydrogenase, leuB, NAD-dependent isopropylmalate dehydrogenase, Saci_0600, SbIPMDH, SoIPMDH, threo-Ds-3-isopropylmalate dehydrogenase, Tt-beta-3-isopropylmalateDH, two-domain 3-isopropylmalate dehydrogenase, Ydr417cp

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.85 3-isopropylmalate dehydrogenase

Organism

Organism on EC 1.1.1.85 - 3-isopropylmalate dehydrogenase

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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
No 1023
-
-
Manually annotated by BRENDA team
No 1023
-
-
Manually annotated by BRENDA team
gene leuB
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
gene leu2A
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
no 38-2
-
-
Manually annotated by BRENDA team
Bacillus sp. (in: Bacteria) no 38-2
no 38-2
-
-
Manually annotated by BRENDA team
gene leuB
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
gene leu2
SwissProt
Manually annotated by BRENDA team
TIT 01010
-
-
Manually annotated by BRENDA team
M588
-
-
Manually annotated by BRENDA team
i.e. Eremothecium gossypii, gene leu2
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
strain C175/CBS 8195, gene LEU2
SwissProt
Manually annotated by BRENDA team
Kazachstania humilis C175 / CBS 8195
strain C175/CBS 8195, gene LEU2
SwissProt
Manually annotated by BRENDA team
gene leuB
SwissProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
gene leu2
SwissProt
Manually annotated by BRENDA team
gene leu2
SwissProt
Manually annotated by BRENDA team
Shewanella oneidensis MR-1 / ATCC 700550
-
UniProt
Manually annotated by BRENDA team
two ancestral sequences of 3-isopropylmalate dehydrogenase (ancIPMDH-IQ and ancIPMDH-ML) are designed by an ancestral sequence reconstruction technique based on a phylogenetic analysis of extant homologous amino acid sequences. Genes encoding the designed sequences are artificially synthesized and expressed in Escherichia coli. They have considerably higher low-temperature catalytic activity as compared with the Thermus thermophilus enzyme
-
-
Manually annotated by BRENDA team
gene leuB
SwissProt
Manually annotated by BRENDA team
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
gene leuB
SwissProt
Manually annotated by BRENDA team
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
i.e. Septoria tritici, gene leuC
SwissProt
Manually annotated by BRENDA team
gene leu2
SwissProt
Manually annotated by BRENDA team